Gene description for ZDHHC1
Gene name zinc finger, DHHC-type containing 1
Gene symbol ZDHHC1
Other names/aliases C16orf1
HSU90653
ZNF377
Species Homo sapiens
 Database cross references - ZDHHC1
ExoCarta ExoCarta_29800
Vesiclepedia VP_29800
Entrez Gene 29800
HGNC 17916
UniProt Q8WTX9  
 ZDHHC1 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ZDHHC1
Molecular Function
    DNA binding GO:0003677 NAS
    protein binding GO:0005515 IPI
    palmitoyltransferase activity GO:0016409 IDA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 IBA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 IDA
Biological Process
    positive regulation of defense response to virus by host GO:0002230 IMP
    protein targeting to membrane GO:0006612 IBA
    protein palmitoylation GO:0018345 IDA
    antiviral innate immune response GO:0140374 IBA
    antiviral innate immune response GO:0140374 IMP
    positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    endosome membrane GO:0010008 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ZDHHC1 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ZDHHC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MTA2 9219
Affinity Capture-MS Homo sapiens
2 KRTAP2-4  
Two-hybrid Homo sapiens
3 KRT83  
Two-hybrid Homo sapiens
4 KRTAP17-1  
Two-hybrid Homo sapiens
5 KRTAP10-8  
Two-hybrid Homo sapiens
6 KRTAP12-2  
Two-hybrid Homo sapiens
7 DDI2 84301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 KRT34  
Two-hybrid Homo sapiens
9 NBPF19  
Two-hybrid Homo sapiens
10 KRTAP12-3  
Two-hybrid Homo sapiens
11 MDFI  
Two-hybrid Homo sapiens
12 NOTCH2NL 388677
Two-hybrid Homo sapiens
13 LGR4 55366
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TAOK2 9344
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 KRTAP1-3  
Two-hybrid Homo sapiens
16 KRTAP1-1  
Two-hybrid Homo sapiens
17 PIK3CB 5291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CYSRT1 375791
Two-hybrid Homo sapiens
19 KRTAP9-2  
Two-hybrid Homo sapiens
20 KRTAP2-3  
Two-hybrid Homo sapiens
21 PIK3CA 5290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZDHHC1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here