Gene description for DDI2
Gene name DNA-damage inducible 1 homolog 2 (S. cerevisiae)
Gene symbol DDI2
Other names/aliases -
Species Homo sapiens
 Database cross references - DDI2
ExoCarta ExoCarta_84301
Vesiclepedia VP_84301
Entrez Gene 84301
HGNC 24578
UniProt Q5TDH0  
 DDI2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DDI2
Molecular Function
    aspartic-type endopeptidase activity GO:0004190 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IDA
    ubiquitin binding GO:0043130 IDA
Biological Process
    proteasomal protein catabolic process GO:0010498 IMP
    protein processing GO:0016485 IDA
    protein processing GO:0016485 IMP
    regulation of protein stability GO:0031647 IMP
    cellular response to hydroxyurea GO:0072711 IMP
    regulation of DNA stability GO:0097752 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    chromosome GO:0005694 IEA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified DDI2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DDI2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG3 9531
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
2 TLN2 83660
Co-fractionation Homo sapiens
3 LDHAL6A  
Affinity Capture-MS Homo sapiens
4 C7orf69  
Affinity Capture-MS Homo sapiens
5 FOXD4L6  
Affinity Capture-MS Homo sapiens
6 MAGEF1  
Affinity Capture-MS Homo sapiens
7 FAM129B 64855
Co-fractionation Homo sapiens
8 ZNF577  
Affinity Capture-MS Homo sapiens
9 DDI1  
Affinity Capture-MS Homo sapiens
10 METTL14  
Co-fractionation Homo sapiens
11 TP53 7157
Affinity Capture-MS Homo sapiens
12 TTC4  
Co-fractionation Homo sapiens
13 RAD23B 5887
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NAA15 80155
Co-fractionation Homo sapiens
15 TSGA10IP  
Affinity Capture-MS Homo sapiens
16 ZDHHC1 29800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
18 UBE3A 7337
Reconstituted Complex Homo sapiens
19 PSMA2 5683
Affinity Capture-MS Homo sapiens
20 CCDC6 8030
Co-fractionation Homo sapiens
21 TRMT6 51605
Co-fractionation Homo sapiens
22 PARK2  
Affinity Capture-MS Homo sapiens
23 ELMOD3  
Affinity Capture-MS Homo sapiens
24 USP47 55031
Affinity Capture-MS Homo sapiens
25 MOGAT2  
Affinity Capture-MS Homo sapiens
26 NR1H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 SUZ12  
Affinity Capture-MS Homo sapiens
28 SLC25A23  
Affinity Capture-MS Homo sapiens
29 PSMD14 10213
Affinity Capture-Western Homo sapiens
30 JAZF1  
Affinity Capture-MS Homo sapiens
31 VPS26A 9559
Co-fractionation Homo sapiens
32 SHFM1 7979
Affinity Capture-Western Homo sapiens
33 RDH5 5959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FAM81B  
Affinity Capture-MS Homo sapiens
35 CDH1 999
Negative Genetic Homo sapiens
36 EYA4 2070
Affinity Capture-MS Homo sapiens
37 CYP2B6  
Affinity Capture-MS Homo sapiens
38 NRIP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 RNF166  
Affinity Capture-MS Homo sapiens
40 ZG16B 124220
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PLD2 5338
Affinity Capture-MS Homo sapiens
42 HP1BP3 50809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PSMC5 5705
Affinity Capture-Western Homo sapiens
44 CPXCR1  
Affinity Capture-MS Homo sapiens
45 PSMB5 5693
Affinity Capture-Western Homo sapiens
46 SUV39H1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 COA7  
Co-fractionation Homo sapiens
48 HYPK 25764
Co-fractionation Homo sapiens
49 HAT1 8520
Co-fractionation Homo sapiens
50 TOM1 10043
Co-fractionation Homo sapiens
51 C1QC 714
Affinity Capture-MS Homo sapiens
52 CPNE2 221184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 NAA10 8260
Co-fractionation Homo sapiens
54 UCHL5 51377
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DDI2 is involved
No pathways found





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