Gene description for SHFM1
Gene name split hand/foot malformation (ectrodactyly) type 1
Gene symbol SHFM1
Other names/aliases DSS1
ECD
SEM1
SHFD1
SHSF1
Shfdg1
Species Homo sapiens
 Database cross references - SHFM1
ExoCarta ExoCarta_7979
Vesiclepedia VP_7979
Entrez Gene 7979
HGNC 10845
MIM 601285
UniProt P60896  
 SHFM1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for SHFM1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    double-strand break repair via homologous recombination GO:0000724 IEA
    mRNA export from nucleus GO:0006406 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 NAS
    proteasome assembly GO:0043248 IEA
Subcellular Localization
    proteasome complex GO:0000502 IDA
    proteasome complex GO:0000502 NAS
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 TAS
    proteasome regulatory particle, lid subcomplex GO:0008541 IEA
    integrator complex GO:0032039 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified SHFM1 in exosomes
1
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SHFM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INTS4  
Affinity Capture-MS Homo sapiens
2 PSME2 5721
Affinity Capture-MS Homo sapiens
3 PSMA6 5687
Affinity Capture-MS Homo sapiens
4 UBL4A 8266
Affinity Capture-MS Homo sapiens
5 EEF1G 1937
Affinity Capture-MS Homo sapiens
6 FBXO7 25793
Affinity Capture-MS Homo sapiens
7 PSMD6 9861
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
8 ZFAND2B  
Affinity Capture-MS Homo sapiens
9 EIF3C 8663
Affinity Capture-MS Homo sapiens
10 RBM15B  
Affinity Capture-MS Homo sapiens
11 PSMD11 5717
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
12 INTS10  
Affinity Capture-MS Homo sapiens
13 BRCA1 672
Two-hybrid Homo sapiens
14 UBE3A 7337
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
15 UBC 7316
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
16 PSMD10 5716
Affinity Capture-MS Homo sapiens
17 LTN1 26046
Affinity Capture-MS Homo sapiens
18 INTS9 55756
Affinity Capture-MS Homo sapiens
19 MAP1LC3B 81631
Two-hybrid Homo sapiens
20 INTS8  
Affinity Capture-MS Homo sapiens
21 PAAF1 80227
Affinity Capture-MS Homo sapiens
22 PSMG3 84262
Affinity Capture-MS Homo sapiens
23 UBFD1 56061
Affinity Capture-MS Homo sapiens
24 PCID2 55795
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
25 PSMD9 5715
Affinity Capture-MS Homo sapiens
26 PSMD12 5718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PSMC6 5706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 PSMC2 5701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
29 UBQLN1 29979
Affinity Capture-MS Homo sapiens
30 NUB1 51667
Affinity Capture-MS Homo sapiens
31 RPF2 84154
Affinity Capture-MS Homo sapiens
32 RAD51  
Reconstituted Complex Homo sapiens
33 PSMG1 8624
Affinity Capture-MS Homo sapiens
34 INTS6 26512
Affinity Capture-MS Homo sapiens
35 NSFL1C 55968
Affinity Capture-MS Homo sapiens
36 TXNL1 9352
Affinity Capture-MS Homo sapiens
37 USP7 7874
Affinity Capture-MS Homo sapiens
38 UBQLN4 56893
Affinity Capture-MS Homo sapiens
39 PSMC3 5702
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
40 RAD23A 5886
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HSPA8 3312
Affinity Capture-MS Homo sapiens
42 ATXN2 6311
Affinity Capture-MS Homo sapiens
43 PSME3 10197
Affinity Capture-MS Homo sapiens
44 UBR4 23352
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
45 RAD23B 5887
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
46 PSMB4 5692
Affinity Capture-MS Homo sapiens
47 USP14 9097
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
48 PSMD4 5710
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
49 CUL4B 8450
Affinity Capture-MS Homo sapiens
50 PSME1 5720
Affinity Capture-MS Homo sapiens
51 PSMC1 5700
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PSMD14 10213
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 BAG6 7917
Affinity Capture-MS Homo sapiens
54 PSMG2 56984
Affinity Capture-MS Homo sapiens
55 UBE2I 7329
Affinity Capture-MS Homo sapiens
56 BRCA2 675
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
57 UBR5 51366
Affinity Capture-MS Homo sapiens
58 PSMD2 5708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
59 VCP 7415
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
60 CKAP5 9793
Affinity Capture-MS Homo sapiens
61 UBQLN2 29978
Affinity Capture-MS Homo sapiens
62 INTS7  
Affinity Capture-MS Homo sapiens
63 SUMO2 6613
Affinity Capture-MS Homo sapiens
64 CCDC39  
Affinity Capture-MS Homo sapiens
65 HECTD1 25831
Affinity Capture-MS Homo sapiens
66 CUL2 8453
Affinity Capture-MS Homo sapiens
67 DDX39B 7919
Affinity Capture-MS Homo sapiens
68 SND1 27044
Affinity Capture-MS Homo sapiens
69 UCHL5 51377
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
70 POLR2B 5431
Affinity Capture-MS Homo sapiens
71 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
72 UFD1L 7353
Affinity Capture-MS Homo sapiens
73 RNF219  
Affinity Capture-MS Homo sapiens
74 NARF 26502
Affinity Capture-MS Homo sapiens
75 PRPF4B 8899
Affinity Capture-MS Homo sapiens
76 RNF181  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
77 TRIM33 51592
Affinity Capture-MS Homo sapiens
78 USP15 9958
Affinity Capture-MS Homo sapiens
79 BAG2 9532
Affinity Capture-MS Homo sapiens
80 PSMD13 5719
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 PSMD8 5714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
82 EEF2 1938
Affinity Capture-MS Homo sapiens
83 USP38 84640
Affinity Capture-MS Homo sapiens
84 UBR7  
Affinity Capture-MS Homo sapiens
85 WDR63 126820
Affinity Capture-MS Homo sapiens
86 TXNRD1 7296
Affinity Capture-MS Homo sapiens
87 PSMA2 5683
Affinity Capture-MS Homo sapiens
88 EGFR 1956
Negative Genetic Homo sapiens
89 YY1 7528
Affinity Capture-MS Homo sapiens
90 CUL1 8454
Affinity Capture-MS Homo sapiens
91 RBM33  
Affinity Capture-MS Homo sapiens
92 EIF3A 8661
Affinity Capture-MS Homo sapiens
93 UBR1 197131
Affinity Capture-MS Homo sapiens
94 PIAS1 8554
Affinity Capture-MS Homo sapiens
95 UBLCP1  
Affinity Capture-MS Homo sapiens
96 BAG1 573
Affinity Capture-MS Homo sapiens
97 TOP1 7150
Affinity Capture-MS Homo sapiens
98 EEF1A2 1917
Affinity Capture-MS Homo sapiens
99 PSMC5 5705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 SAC3D1  
Affinity Capture-MS Homo sapiens
101 MDN1 23195
Affinity Capture-MS Homo sapiens
102 KIAA0368 23392
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
103 ADRM1 11047
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
104 CPSF3L 54973
Affinity Capture-MS Homo sapiens
105 INTS5 80789
Affinity Capture-MS Homo sapiens
106 PSMD7 5713
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
107 PSMB1 5689
Affinity Capture-MS Homo sapiens
108 MARCH6  
Affinity Capture-MS Homo sapiens
109 HUWE1 10075
Affinity Capture-MS Homo sapiens
110 EEF1A1 1915
Affinity Capture-MS Homo sapiens
111 STUB1 10273
Affinity Capture-MS Homo sapiens
112 TLN2 83660
Affinity Capture-MS Homo sapiens
113 DNAH6 1768
Affinity Capture-MS Homo sapiens
114 NUDT21 11051
Two-hybrid Homo sapiens
115 UBE3B 89910
Affinity Capture-MS Homo sapiens
116 PRRC2A 7916
Affinity Capture-MS Homo sapiens
117 SIN3A  
Affinity Capture-MS Homo sapiens
118 FEN1 2237
Affinity Capture-MS Homo sapiens
119 UBE2G2  
Affinity Capture-MS Homo sapiens
120 UBA7 7318
Affinity Capture-MS Homo sapiens
121 PRRC2C 23215
Affinity Capture-MS Homo sapiens
122 RPA1 6117
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
123 POMP  
Affinity Capture-MS Homo sapiens
124 LENG8  
Affinity Capture-MS Homo sapiens
125 RNF126  
Affinity Capture-MS Homo sapiens
126 INTS2  
Affinity Capture-MS Homo sapiens
127 TAF2  
Affinity Capture-MS Homo sapiens
128 DDX58 23586
Affinity Capture-RNA Homo sapiens
129 UBE3C 9690
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
130 PSMA7 5688
Affinity Capture-MS Homo sapiens
131 PSMF1 9491
Affinity Capture-MS Homo sapiens
132 DDX42 11325
Affinity Capture-MS Homo sapiens
133 DDI2 84301
Affinity Capture-Western Homo sapiens
134 KRAS 3845
Negative Genetic Homo sapiens
135 HNRNPU 3192
Affinity Capture-MS Homo sapiens
136 PSMD1 5707
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 PSMC4 5704
Affinity Capture-MS Homo sapiens
138 NEDD8 4738
Affinity Capture-MS Homo sapiens
139 PSMD3 5709
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
140 PSME4 23198
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SHFM1 is involved
PathwayEvidenceSource
ABC transporter disorders TAS Reactome
ABC-family proteins mediated transport TAS Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
Activation of NF-kappaB in B cells TAS Reactome
Adaptive Immune System IEA Reactome
Adaptive Immune System TAS Reactome
Antigen processing-Cross presentation IEA Reactome
Antigen processing-Cross presentation TAS Reactome
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome
APC/C-mediated degradation of cell cycle proteins TAS Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Securin TAS Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 TAS Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint TAS Reactome
Apoptosis IEA Reactome
Assembly of the pre-replicative complex TAS Reactome
Asymmetric localization of PCP proteins TAS Reactome
AUF1 (hnRNP D0) binds and destabilizes mRNA TAS Reactome
Autodegradation of Cdh1 by Cdh1:APC/C TAS Reactome
Autodegradation of the E3 ubiquitin ligase COP1 TAS Reactome
Axon guidance IEA Reactome
Beta-catenin independent WNT signaling TAS Reactome
C-type lectin receptors (CLRs) TAS Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A TAS Reactome
CDK-mediated phosphorylation and removal of Cdc6 TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular response to chemical stress TAS Reactome
Cellular response to hypoxia TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Class I MHC mediated antigen processing & presentation IEA Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
Cross-presentation of soluble exogenous antigens (endosomes) TAS Reactome
Cyclin A:Cdk2-associated events at S phase entry TAS Reactome
Cyclin E associated events during G1/S transition TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Dectin-1 mediated noncanonical NF-kB signaling TAS Reactome
Defective CFTR causes cystic fibrosis TAS Reactome
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function TAS Reactome
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function TAS Reactome
Defective homologous recombination repair (HRR) due to BRCA1 loss of function TAS Reactome
Defective homologous recombination repair (HRR) due to BRCA2 loss of function TAS Reactome
Defective homologous recombination repair (HRR) due to PALB2 loss of function TAS Reactome
Degradation of AXIN TAS Reactome
Degradation of beta-catenin by the destruction complex TAS Reactome
Degradation of DVL TAS Reactome
Degradation of GLI1 by the proteasome TAS Reactome
Degradation of GLI2 by the proteasome IEA Reactome
Deubiquitination TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of DNA Double-Strand Break Repair TAS Reactome
Diseases of DNA repair TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Disorders of transmembrane transporters TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA Repair TAS Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Downstream signaling events of B Cell Receptor (BCR) TAS Reactome
Downstream TCR signaling TAS Reactome
ER-Phagosome pathway IEA Reactome
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated NF-kB activation TAS Reactome
Formation of paraxial mesoderm IEA Reactome
G1/S DNA Damage Checkpoints TAS Reactome
G1/S Transition TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M Transition TAS Reactome
Gastrulation IEA Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
GLI3 is processed to GLI3R by the proteasome TAS Reactome
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 TAS Reactome
HDR through Homologous Recombination (HRR) TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Hedgehog 'off' state IEA Reactome
Hedgehog 'off' state TAS Reactome
Hedgehog 'on' state TAS Reactome
Hedgehog ligand biogenesis TAS Reactome
Hh mutants abrogate ligand secretion TAS Reactome
Hh mutants are degraded by ERAD TAS Reactome
HIV Infection TAS Reactome
Homologous DNA Pairing and Strand Exchange TAS Reactome
Homology Directed Repair TAS Reactome
Host Interactions of HIV factors TAS Reactome
Immune System IEA Reactome
Immune System TAS Reactome
Impaired BRCA2 binding to RAD51 TAS Reactome
Impaired BRCA2 binding to SEM1 (DSS1) TAS Reactome
Impaired BRCA2 translocation to the nucleus TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
KEAP1-NFE2L2 pathway TAS Reactome
M Phase TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MAPK6/MAPK4 signaling TAS Reactome
Metabolism TAS Reactome
Metabolism of amino acids and derivatives TAS Reactome
Metabolism of polyamines TAS Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic G1 phase and G1/S transition TAS Reactome
Mitotic G2-G2/M phases TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Neddylation TAS Reactome
Negative regulation of NOTCH4 signaling IEA Reactome
Nervous system development IEA Reactome
NIK-->noncanonical NF-kB signaling TAS Reactome
Nuclear events mediated by NFE2L2 TAS Reactome
Orc1 removal from chromatin TAS Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TAS Reactome
p53-Dependent G1 DNA Damage Response TAS Reactome
p53-Dependent G1/S DNA damage checkpoint TAS Reactome
p53-Independent DNA Damage Response TAS Reactome
p53-Independent G1/S DNA damage checkpoint TAS Reactome
PCP/CE pathway TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein modification IEA Reactome
Presynaptic phase of homologous DNA pairing and strand exchange TAS Reactome
Programmed Cell Death IEA Reactome
Proteasome assembly TAS Reactome
Proteasome assembly IEA Reactome
PTEN Regulation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of activated PAK-2p34 by proteasome mediated degradation IEA Reactome
Regulation of APC/C activators between G1/S and early anaphase TAS Reactome
Regulation of Apoptosis IEA Reactome
Regulation of expression of SLITs and ROBOs IEA Reactome
Regulation of mitotic cell cycle TAS Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements TAS Reactome
Regulation of ornithine decarboxylase (ODC) TAS Reactome
Regulation of PTEN stability and activity TAS Reactome
Regulation of RAS by GAPs TAS Reactome
Regulation of RUNX2 expression and activity IEA Reactome
Regulation of RUNX2 expression and activity TAS Reactome
Regulation of RUNX3 expression and activity TAS Reactome
Resolution of D-Loop Structures TAS Reactome
Resolution of D-loop Structures through Holliday Junction Intermediates TAS Reactome
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs TAS Reactome
S Phase TAS Reactome
SCF(Skp2)-mediated degradation of p27/p21 TAS Reactome
SCF-beta-TrCP mediated degradation of Emi1 TAS Reactome
Separation of Sister Chromatids TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by Hedgehog TAS Reactome
Signaling by Hedgehog IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH4 IEA Reactome
Signaling by ROBO receptors IEA Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by WNT TAS Reactome
Somitogenesis IEA Reactome
Stabilization of p53 TAS Reactome
Switching of origins to a post-replicative state TAS Reactome
Synthesis of DNA TAS Reactome
TCF dependent signaling in response to WNT TAS Reactome
TCR signaling TAS Reactome
The role of GTSE1 in G2/M progression after G2 checkpoint TAS Reactome
TNFR2 non-canonical NF-kB pathway TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX2 IEA Reactome
Transcriptional regulation by RUNX2 TAS Reactome
Transcriptional regulation by RUNX3 TAS Reactome
Transport of small molecules TAS Reactome
Ub-specific processing proteases TAS Reactome
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TAS Reactome
Ubiquitin-dependent degradation of Cyclin D TAS Reactome
UCH proteinases TAS Reactome
Vif-mediated degradation of APOBEC3G TAS Reactome
Viral Infection Pathways TAS Reactome
Vpu mediated degradation of CD4 TAS Reactome





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