Gene description for WDR63
Gene name WD repeat domain 63
Gene symbol WDR63
Other names/aliases DIC3
NYD-SP29
Species Homo sapiens
 Database cross references - WDR63
ExoCarta ExoCarta_126820
Vesiclepedia VP_126820
Entrez Gene 126820
HGNC 30711
UniProt Q8IWG1  
 WDR63 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for WDR63
Molecular Function
    protein binding GO:0005515 IPI
    dynein light chain binding GO:0045503 IBA
    dynein heavy chain binding GO:0045504 IBA
    Arp2/3 complex binding GO:0071933 IDA
Biological Process
    negative regulation of cell migration GO:0030336 IMP
    negative regulation of Arp2/3 complex-mediated actin nucleation GO:0034316 IMP
    inner dynein arm assembly GO:0036159 IBA
    positive regulation of osteoblast differentiation GO:0045669 ISS
    cilium movement involved in cell motility GO:0060294 IBA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    axonemal dynein complex GO:0005858 ISS
    inner dynein arm GO:0036156 IBA
 Experiment description of studies that identified WDR63 in sEVs
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for WDR63
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OGDHL  
Affinity Capture-MS Homo sapiens
2 SHFM1 7979
Affinity Capture-MS Homo sapiens
3 GALM 130589
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which WDR63 is involved
No pathways found





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