Gene description for LTN1
Gene name listerin E3 ubiquitin protein ligase 1
Gene symbol LTN1
Other names/aliases C21orf10
C21orf98
RNF160
ZNF294
Species Homo sapiens
 Database cross references - LTN1
ExoCarta ExoCarta_26046
Vesiclepedia VP_26046
Entrez Gene 26046
HGNC 13082
MIM 613083
UniProt O94822  
 LTN1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for LTN1
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ribosomal large subunit binding GO:0043023 IBA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    protein autoubiquitination GO:0051865 IEA
    rescue of stalled ribosome GO:0072344 IBA
    rescue of stalled ribosome GO:0072344 IDA
    ribosome-associated ubiquitin-dependent protein catabolic process GO:1990116 IBA
    ribosome-associated ubiquitin-dependent protein catabolic process GO:1990116 IDA
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosolic ribosome GO:0022626 IDA
    RQC complex GO:1990112 IBA
    RQC complex GO:1990112 IDA
 Experiment description of studies that identified LTN1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LTN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 TGOLN2 10618
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SLFN11 91607
Affinity Capture-MS Homo sapiens
4 Sgol2  
Affinity Capture-MS Mus musculus
5 Cul1 26965
Affinity Capture-MS Mus musculus
6 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HCST  
Affinity Capture-MS Homo sapiens
8 Nek2  
Affinity Capture-MS Mus musculus
9 TRIM66  
Affinity Capture-MS Homo sapiens
10 IGHM 3507
Affinity Capture-MS Homo sapiens
11 C9orf78 51759
Affinity Capture-MS Homo sapiens
12 UBC 7316
Biochemical Activity Homo sapiens
13 PTPN1 5770
Affinity Capture-MS Homo sapiens
14 ASXL1  
Affinity Capture-MS Homo sapiens
15 Cenpq  
Affinity Capture-MS Mus musculus
16 CEP97 79598
Affinity Capture-MS Homo sapiens
17 HPX 3263
Affinity Capture-MS Homo sapiens
18 PSIP1 11168
Co-fractionation Homo sapiens
19 FCGR3A  
Affinity Capture-MS Homo sapiens
20 HLA-B 3106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 FAM174A 345757
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SSR1 6745
Affinity Capture-Western Homo sapiens
23 CHMP2B 25978
Affinity Capture-MS Homo sapiens
24 SRP14 6727
Affinity Capture-MS Homo sapiens
25 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 DHCR7 1717
Affinity Capture-MS Homo sapiens
27 DGCR2 9993
Affinity Capture-MS Homo sapiens
28 XRCC3  
Affinity Capture-MS Homo sapiens
29 KCNMB3  
Affinity Capture-MS Homo sapiens
30 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 GPR17 2840
Affinity Capture-MS Homo sapiens
32 RNF11 26994
Affinity Capture-MS Homo sapiens
33 FEN1 2237
Affinity Capture-MS Homo sapiens
34 KRT8 3856
Proximity Label-MS Homo sapiens
35 IRAK4 51135
Co-fractionation Homo sapiens
36 ARRDC4  
Affinity Capture-MS Homo sapiens
37 MAPK3 5595
Affinity Capture-MS Homo sapiens
38 ILKAP 80895
Affinity Capture-MS Homo sapiens
39 C19orf38  
Affinity Capture-MS Homo sapiens
40 CTDP1 9150
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 IRF7  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
42 IL2RA  
Affinity Capture-MS Homo sapiens
43 ARRDC2  
Affinity Capture-MS Homo sapiens
44 NTRK1 4914
Affinity Capture-MS Homo sapiens
45 UBE2L3 7332
Reconstituted Complex Homo sapiens
46 GPR182  
Affinity Capture-MS Homo sapiens
47 SEC61B 10952
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
48 TIRAP  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
49 SP100 6672
Affinity Capture-MS Homo sapiens
50 B3GALT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CD40 958
Affinity Capture-MS Homo sapiens
52 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 PNPT1 87178
Affinity Capture-MS Homo sapiens
54 UGGT1 56886
Affinity Capture-MS Homo sapiens
55 EIF6 3692
Proximity Label-MS Homo sapiens
56 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 LRRC25  
Affinity Capture-MS Homo sapiens
58 NPTN 27020
Affinity Capture-MS Homo sapiens
59 IQCB1  
Affinity Capture-MS Homo sapiens
60 CUL3 8452
Affinity Capture-MS Homo sapiens
61 MBOAT1  
Affinity Capture-MS Homo sapiens
62 NPY2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 EGFR 1956
Affinity Capture-MS Homo sapiens
64 Evpl  
Affinity Capture-MS Mus musculus
65 CLSPN  
Affinity Capture-MS Homo sapiens
66 Trappc8  
Affinity Capture-MS Mus musculus
67 CD226 10666
Affinity Capture-MS Homo sapiens
68 TMEM173  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
69 HES4  
Reconstituted Complex Homo sapiens
70 UBE2D2 7322
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
71 C3orf18  
Affinity Capture-MS Homo sapiens
72 BAG1 573
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
73 CD244 51744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 PTPRN  
Affinity Capture-MS Homo sapiens
75 DUSP9  
Affinity Capture-MS Homo sapiens
76 P2RY10  
Affinity Capture-MS Homo sapiens
77 KRAS 3845
Synthetic Lethality Homo sapiens
78 ZRANB1 54764
Affinity Capture-MS Homo sapiens
79 DENND6A 201627
Proximity Label-MS Homo sapiens
80 Tor1aip1  
Affinity Capture-MS Mus musculus
81 KIF2A 3796
Affinity Capture-MS Homo sapiens
82 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
83 ALDH3A2 224
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 TMEM9 252839
Affinity Capture-MS Homo sapiens
85 RPL6 6128
Affinity Capture-Western Homo sapiens
86 NMI  
Co-fractionation Homo sapiens
87 RNF19B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 RPA1 6117
Co-fractionation Homo sapiens
89 AGO1  
PCA Homo sapiens
90 NPAT  
Affinity Capture-MS Homo sapiens
91 SHFM1 7979
Affinity Capture-MS Homo sapiens
92 NEMF 9147
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
93 Shoc2  
Affinity Capture-MS Mus musculus
94 FCER1A  
Affinity Capture-MS Homo sapiens
95 SLAMF1 6504
Affinity Capture-MS Homo sapiens
96 CCDC93 54520
Affinity Capture-MS Homo sapiens
97 CHRM3 1131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 KIR2DS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 PLD3 23646
Affinity Capture-MS Homo sapiens
100 PARD6B 84612
Affinity Capture-MS Homo sapiens
101 KIF18B 146909
Affinity Capture-MS Homo sapiens
102 TET3  
Affinity Capture-MS Homo sapiens
103 SPACA1 81833
Affinity Capture-MS Homo sapiens
104 BRD1 23774
Affinity Capture-MS Homo sapiens
105 KIR2DL4  
Affinity Capture-MS Homo sapiens
106 PRPF19 27339
Co-fractionation Homo sapiens
107 TAP1 6890
Affinity Capture-MS Homo sapiens
108 VASN 114990
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 RPA3 6119
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
110 OPALIN  
Affinity Capture-MS Homo sapiens
111 DKKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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