Gene description for CD244
Gene name CD244 molecule, natural killer cell receptor 2B4
Gene symbol CD244
Other names/aliases 2B4
NAIL
NKR2B4
Nmrk
SLAMF4
Species Homo sapiens
 Database cross references - CD244
ExoCarta ExoCarta_51744
Vesiclepedia VP_51744
Entrez Gene 51744
HGNC 18171
MIM 605554
UniProt Q9BZW8  
 CD244 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CD244
Molecular Function
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 IDA
    MHC class I protein binding GO:0042288 IBA
    MHC class I protein binding GO:0042288 IDA
Biological Process
    adaptive immune response GO:0002250 IEA
    natural killer cell activation involved in immune response GO:0002323 IBA
    natural killer cell activation involved in immune response GO:0002323 IDA
    immune response GO:0006955 IBA
    signal transduction GO:0007165 TAS
    natural killer cell activation GO:0030101 IDA
    positive regulation of type II interferon production GO:0032729 IDA
    positive regulation of interleukin-8 production GO:0032757 IDA
    innate immune response GO:0045087 IEA
    positive regulation of inositol phosphate biosynthetic process GO:0060732 IDA
    positive regulation of granzyme B production GO:0071663 IDA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
    membrane raft GO:0045121 IEA
 Experiment description of studies that identified CD244 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CD244
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IMMT 10989
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 POMT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 HEATR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RAB18 22931
Affinity Capture-MS Homo sapiens
5 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 POMT1 10585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 UFSP2 55325
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ELMO3 79767
Affinity Capture-MS Homo sapiens
9 C1orf27 54953
Affinity Capture-MS Homo sapiens
10 SAMM50 25813
Affinity Capture-MS Homo sapiens
11 CTPS2 56474
Affinity Capture-MS Homo sapiens
12 ATP1A4 480
Affinity Capture-MS Homo sapiens
13 MTX2 10651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GPN3  
Affinity Capture-MS Homo sapiens
15 CAND2 23066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LTN1 26046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 BZRAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ST7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PI4KA 5297
Affinity Capture-MS Homo sapiens
20 MYADM 91663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RNF213 57674
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PDXDC1 23042
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 UBR1 197131
Affinity Capture-MS Homo sapiens
24 C9orf89 84270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 FYN 2534
Affinity Capture-Western Homo sapiens
26 SH2D1A 4068
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 MTOR 2475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CHCHD6 84303
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SRC 6714
Affinity Capture-MS Homo sapiens
30 PIK3R1 5295
Affinity Capture-MS Homo sapiens
31 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
32 HEATR1 55127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 TNFAIP2 7127
Affinity Capture-MS Homo sapiens
34 MTX3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ATP13A1 57130
Affinity Capture-MS Homo sapiens
36 C9orf156  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CD244 is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome
Hemostasis TAS Reactome





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