Gene description for POMT1
Gene name protein-O-mannosyltransferase 1
Gene symbol POMT1
Other names/aliases LGMD2K
MDDGA1
MDDGB1
MDDGC1
RT
Species Homo sapiens
 Database cross references - POMT1
ExoCarta ExoCarta_10585
Vesiclepedia VP_10585
Entrez Gene 10585
HGNC 9202
MIM 607423
UniProt Q9Y6A1  
 POMT1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for POMT1
Molecular Function
    mannosyltransferase activity GO:0000030 IMP
    dolichyl-phosphate-mannose-protein mannosyltransferase activity GO:0004169 IEA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    protein O-linked glycosylation GO:0006493 TAS
    extracellular matrix organization GO:0030198 IEA
    protein O-linked mannosylation GO:0035269 IMP
    positive regulation of protein O-linked glycosylation GO:1904100 IEA
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    endoplasmic reticulum GO:0005783 TAS
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 TAS
    sarcoplasmic reticulum GO:0016529 IEA
    dolichyl-phosphate-mannose-protein mannosyltransferase complex GO:0031502 IEA
 Experiment description of studies that identified POMT1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for POMT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NRG1 3084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 APOC3 345
Affinity Capture-MS Homo sapiens
3 VWCE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 NRROS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ATP1B4  
Affinity Capture-MS Homo sapiens
9 PCDHB7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MEX3A  
Affinity Capture-RNA Homo sapiens
11 CHRNA4  
Affinity Capture-MS Homo sapiens
12 TTYH1  
Affinity Capture-MS Homo sapiens
13 GABRE  
Affinity Capture-MS Homo sapiens
14 PCDHA8  
Affinity Capture-MS Homo sapiens
15 POMK  
Affinity Capture-MS Homo sapiens
16 GABRA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ZDHHC12  
Affinity Capture-MS Homo sapiens
18 HPN  
Affinity Capture-MS Homo sapiens
19 PCDHGB4 8641
Affinity Capture-MS Homo sapiens
20 IL9R  
Affinity Capture-MS Homo sapiens
21 TMPRSS12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SYNE4  
Affinity Capture-MS Homo sapiens
23 B4GAT1 11041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 PCDHB6  
Affinity Capture-MS Homo sapiens
25 GGT7 2686
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ATP1B3 483
Affinity Capture-MS Homo sapiens
27 APEX1 328
Affinity Capture-RNA Homo sapiens
28 CLEC12B  
Affinity Capture-MS Homo sapiens
29 CHRNB2  
Affinity Capture-MS Homo sapiens
30 SLC3A2 6520
Affinity Capture-MS Homo sapiens
31 FBXO2 26232
Affinity Capture-MS Homo sapiens
32 CD1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 A4GNT  
Affinity Capture-MS Homo sapiens
34 VNN2  
Affinity Capture-MS Homo sapiens
35 NCEH1 57552
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 HFE  
Affinity Capture-MS Homo sapiens
37 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CD244 51744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 PCDHA4 56144
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 MEOX2  
Two-hybrid Homo sapiens
41 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ST14 6768
Affinity Capture-MS Homo sapiens
43 UPK1A 11045
Affinity Capture-MS Homo sapiens
44 HTR3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 CANX 821
Affinity Capture-MS Homo sapiens
46 BTNL8  
Affinity Capture-MS Homo sapiens
47 SCNN1D  
Affinity Capture-MS Homo sapiens
48 KCNK16  
Affinity Capture-MS Homo sapiens
49 TMEM92  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 RFTN2 130132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 NSDHL 50814
Affinity Capture-MS Homo sapiens
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