Gene description for SH2D1A
Gene name SH2 domain containing 1A
Gene symbol SH2D1A
Other names/aliases DSHP
EBVS
IMD5
LYP
MTCP1
SAP
SAP/SH2D1A
XLP
XLPD
XLPD1
Species Homo sapiens
 Database cross references - SH2D1A
ExoCarta ExoCarta_4068
Vesiclepedia VP_4068
Entrez Gene 4068
HGNC 10820
MIM 300490
UniProt O60880  
 SH2D1A identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for SH2D1A
Molecular Function
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 IDA
Biological Process
    adaptive immune response GO:0002250 IEA
    humoral immune response GO:0006959 IEA
    cellular defense response GO:0006968 IEA
    cell-cell signaling GO:0007267 IEA
    natural killer cell activation GO:0030101 IDA
    natural killer cell mediated cytotoxicity GO:0042267 IEA
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 IEA
    regulation of immune response GO:0050776 IMP
    negative regulation of T cell receptor signaling pathway GO:0050860 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified SH2D1A in sEVs
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SH2D1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LHX4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 TNK2 10188
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 ERBB2 2064
Reconstituted Complex Homo sapiens
4 NIF3L1 60491
Affinity Capture-MS Homo sapiens
5 KIT 3815
Reconstituted Complex Homo sapiens
6 ERBB4 2066
Reconstituted Complex Homo sapiens
7 LY9 4063
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 EGFR 1956
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
9 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
10 ERBB3 2065
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
11 DOK1 1796
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
12 LRRFIP2 9209
Affinity Capture-MS Homo sapiens
13 FYN 2534
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
14 LHX3  
Two-hybrid Homo sapiens
15 CD84 8832
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 CD244 51744
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 MET 4233
Reconstituted Complex Homo sapiens
18 SLAMF6 114836
Affinity Capture-Western Homo sapiens
19 MDP1 145553
Affinity Capture-MS Homo sapiens
20 AR 367
Reconstituted Complex Homo sapiens
21 MAPK14 1432
Biochemical Activity Homo sapiens
22 SLAMF1 6504
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
23 NEDD8-MDP1 100528064
Affinity Capture-MS Homo sapiens
24 MAPK11  
Biochemical Activity Homo sapiens
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