Gene description for SH2D1A
Gene name SH2 domain containing 1A
Gene symbol SH2D1A
Other names/aliases DSHP
EBVS
IMD5
LYP
MTCP1
SAP
SAP/SH2D1A
XLP
XLPD
XLPD1
Species Homo sapiens
 Database cross references - SH2D1A
ExoCarta ExoCarta_4068
Entrez Gene 4068
HGNC 10820
MIM 300490
UniProt O60880  
 SH2D1A identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for SH2D1A
Molecular Function
    SH3/SH2 adaptor activity GO:0005070 NAS
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of signal transduction GO:0009967 NAS
    cell-cell signaling GO:0007267 IDA
    humoral immune response GO:0006959 IEA
    cellular defense response GO:0006968 NAS
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified SH2D1A in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SH2D1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLAMF6 114836
Invivo Homo sapiens
Invitro Homo sapiens
2 CD244  
Invitro Homo sapiens
Invivo Homo sapiens
3 DOK1 1796
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 LY9 4063
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
5 FYN 2534
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 CD84 8832
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 SLAMF1 6504
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SH2D1A is involved
No pathways found





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