Gene description for CHRM3
Gene name cholinergic receptor, muscarinic 3
Gene symbol CHRM3
Other names/aliases EGBRS
HM3
Species Homo sapiens
 Database cross references - CHRM3
ExoCarta ExoCarta_1131
Vesiclepedia VP_1131
Entrez Gene 1131
HGNC 1952
MIM 118494
UniProt P20309  
 CHRM3 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CHRM3
Molecular Function
    phosphatidylinositol phospholipase C activity GO:0004435 TAS
    protein binding GO:0005515 IPI
    G protein-coupled acetylcholine receptor activity GO:0016907 IBA
    G protein-coupled acetylcholine receptor activity GO:0016907 ISS
    signaling receptor activity GO:0038023 TAS
    acetylcholine binding GO:0042166 ISS
Biological Process
    smooth muscle contraction GO:0006939 IEA
    regulation of smooth muscle contraction GO:0006940 IBA
    signal transduction GO:0007165 TAS
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 IBA
    adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway GO:0007197 IBA
    phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway GO:0007207 IEA
    G protein-coupled acetylcholine receptor signaling pathway GO:0007213 ISS
    chemical synaptic transmission GO:0007268 IBA
    synaptic transmission, cholinergic GO:0007271 IEA
    nervous system development GO:0007399 TAS
    calcium-mediated signaling GO:0019722 IDA
    positive regulation of insulin secretion GO:0032024 IEA
    regulation of monoatomic ion transmembrane transporter activity GO:0032412 IDA
    protein modification process GO:0036211 TAS
    positive regulation of smooth muscle contraction GO:0045987 IEA
    saliva secretion GO:0046541 IEA
    acetylcholine receptor signaling pathway GO:0095500 IDA
    ion channel modulating, G protein-coupled receptor signaling pathway GO:0099105 IEA
    ligand-gated ion channel signaling pathway GO:1990806 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    basal plasma membrane GO:0009925 IDA
    basolateral plasma membrane GO:0016323 IEA
    dendrite GO:0030425 IBA
    synapse GO:0045202 IBA
    postsynaptic membrane GO:0045211 IEA
 Experiment description of studies that identified CHRM3 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CHRM3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TUBA3C 7278
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SLC4A7 9497
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TTI1 9675
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CD2BP2 10421
Two-hybrid Homo sapiens
5 POM121C  
Two-hybrid Homo sapiens
6 FTSJ1 24140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 USP46 64854
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 FASTKD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 PRKDC 5591
Affinity Capture-MS Homo sapiens
10 GPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 IPO7 10527
Affinity Capture-MS Homo sapiens
12 EXOC2 55770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ATP1A4 480
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ARL10  
Affinity Capture-MS Homo sapiens
15 CSNK1A1 1452
Reconstituted Complex Homo sapiens
16 SEPT3  
Two-hybrid Homo sapiens
17 JPH1 56704
Affinity Capture-MS Homo sapiens
18 CAND2 23066
Affinity Capture-MS Homo sapiens
19 COMMD7 149951
Two-hybrid Homo sapiens
20 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 MAGED2 10916
Two-hybrid Homo sapiens
22 DNAJA3 9093
Affinity Capture-MS Homo sapiens
23 TUBB3 10381
Affinity Capture-MS Homo sapiens
24 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 RANBP6 26953
Affinity Capture-MS Homo sapiens
26 FARP2 9855
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 GBF1 8729
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 HOOK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 LTN1 26046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 GNAS 2778
Two-hybrid Homo sapiens
31 C1orf112  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 STARD3 10948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PI4KA 5297
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 RGS7  
Reconstituted Complex Homo sapiens
35 PEX1 5189
Affinity Capture-MS Homo sapiens
36 PTRH2 51651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ARF6 382
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
38 FLT4  
Affinity Capture-MS Homo sapiens
39 HEATR3 55027
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 PBXIP1 57326
Affinity Capture-MS Homo sapiens
41 ATL2 64225
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 PIK3CB 5291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ATP1A3 478
Affinity Capture-MS Homo sapiens
44 CCDC184  
Two-hybrid Homo sapiens
45 SET 6418
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
46 PIGX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 YIPF4 84272
Affinity Capture-MS Homo sapiens
48 ARF1 375
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
49 TELO2 9894
Affinity Capture-MS Homo sapiens
50 IPO13 9670
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ITPRIPL1  
Affinity Capture-MS Homo sapiens
52 CERS6  
Affinity Capture-MS Homo sapiens
53 SGSM3  
Two-hybrid Homo sapiens
54 NARS2  
Affinity Capture-MS Homo sapiens
55 TAP1 6890
Two-hybrid Homo sapiens
56 YIPF3 25844
Two-hybrid Homo sapiens
57 PPP6R1 22870
Affinity Capture-MS Homo sapiens
58 JAKMIP1 152789
Two-hybrid Homo sapiens
59 DYM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 STX18 53407
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 C10orf35  
Affinity Capture-MS Homo sapiens
62 CALM3 808
Two-hybrid Homo sapiens
63 GTPBP2 54676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 DCP2  
Affinity Capture-MS Homo sapiens
65 CAV1 857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 PIK3R3 8503
Affinity Capture-MS Homo sapiens
67 LRP10 26020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 PLD2 5338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 BSG 682
Two-hybrid Homo sapiens
70 C20orf24  
Two-hybrid Homo sapiens
71 CCRN4L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 TPM3 7170
Two-hybrid Homo sapiens
73 IPO9 55705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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