Gene description for TELO2
Gene name telomere maintenance 2
Gene symbol TELO2
Other names/aliases CLK2
TEL2
Species Homo sapiens
 Database cross references - TELO2
ExoCarta ExoCarta_9894
Vesiclepedia VP_9894
Entrez Gene 9894
HGNC 29099
MIM 611140
UniProt Q9Y4R8  
 TELO2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for TELO2
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IPI
    telomeric DNA binding GO:0042162 IBA
    protein-containing complex binding GO:0044877 IDA
    Hsp90 protein binding GO:0051879 IBA
    Hsp90 protein binding GO:0051879 IPI
    molecular adaptor activity GO:0060090 IEA
Biological Process
    protein stabilization GO:0050821 IMP
    protein stabilization GO:0050821 NAS
    'de novo' cotranslational protein folding GO:0051083 IBA
    positive regulation of DNA damage checkpoint GO:2000003 NAS
Subcellular Localization
    chromosome, telomeric region GO:0000781 IEA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    membrane GO:0016020 IEA
    nuclear body GO:0016604 IDA
    TTT Hsp90 cochaperone complex GO:0110078 IPI
 Experiment description of studies that identified TELO2 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TELO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATR  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 C5AR2  
Affinity Capture-MS Homo sapiens
4 SENP3 26168
Affinity Capture-MS Homo sapiens
5 SPRTN  
Affinity Capture-MS Homo sapiens
6 Ruvbl1 56505
Affinity Capture-MS Mus musculus
7 PSMD6 9861
Affinity Capture-MS Homo sapiens
8 TRRAP 8295
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 C9orf78 51759
Affinity Capture-MS Homo sapiens
10 HLA-B 3106
Affinity Capture-MS Homo sapiens
11 TRIM66  
Affinity Capture-MS Homo sapiens
12 APC  
Affinity Capture-MS Homo sapiens
13 SLC2A1 6513
Affinity Capture-MS Homo sapiens
14 FPR1  
Affinity Capture-MS Homo sapiens
15 ATM 472
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 PRKDC 5591
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
17 SLC18A2  
Affinity Capture-MS Homo sapiens
18 MASTL  
Affinity Capture-MS Homo sapiens
19 RUVBL1 8607
Affinity Capture-MS Homo sapiens
20 CORO1B 57175
Co-fractionation Homo sapiens
21 B3GNT2 10678
Affinity Capture-MS Homo sapiens
22 D2HGDH 728294
Affinity Capture-MS Homo sapiens
23 COPB2 9276
Co-fractionation Homo sapiens
24 FAM174A 345757
Affinity Capture-MS Homo sapiens
25 APLNR  
Affinity Capture-MS Homo sapiens
26 GPR55  
Affinity Capture-MS Homo sapiens
27 DNAJB1 3337
Affinity Capture-MS Homo sapiens
28 TULP3 7289
Affinity Capture-MS Homo sapiens
29 DNAJC7 7266
Proximity Label-MS Homo sapiens
30 F2RL1  
Affinity Capture-MS Homo sapiens
31 PROKR1  
Affinity Capture-MS Homo sapiens
32 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 FAM96A  
Affinity Capture-MS Homo sapiens
34 PTPRN2  
Affinity Capture-MS Homo sapiens
35 CTDP1 9150
Affinity Capture-MS Homo sapiens
36 RUFY1 80230
Co-fractionation Homo sapiens
37 PARK2  
Affinity Capture-MS Homo sapiens
38 P2RY8  
Affinity Capture-MS Homo sapiens
39 COPG1 22820
Co-fractionation Homo sapiens
40 SMEK1 55671
Co-fractionation Homo sapiens
41 VCP 7415
Affinity Capture-MS Homo sapiens
42 NTRK1 4914
Affinity Capture-MS Homo sapiens
43 CRKL 1399
Affinity Capture-MS Homo sapiens
44 GPR182  
Affinity Capture-MS Homo sapiens
45 PPARD  
Affinity Capture-MS Homo sapiens
46 DSP 1832
Affinity Capture-MS Homo sapiens
47 UBXN6 80700
Affinity Capture-MS Homo sapiens
48 CLDN10  
Affinity Capture-MS Homo sapiens
49 TTI1 9675
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
50 CACNA1A  
Two-hybrid Homo sapiens
51 AK2 204
Co-fractionation Homo sapiens
52 AIFM1 9131
Affinity Capture-MS Homo sapiens
53 XPO1 7514
Affinity Capture-MS Homo sapiens
54 PANX1 24145
Proximity Label-MS Homo sapiens
55 NPTN 27020
Affinity Capture-MS Homo sapiens
56 CD274 29126
Affinity Capture-MS Homo sapiens
57 MGARP  
Affinity Capture-MS Homo sapiens
58 CUL3 8452
Affinity Capture-MS Homo sapiens
59 RICTOR 253260
Affinity Capture-Western Homo sapiens
60 NPY2R  
Affinity Capture-MS Homo sapiens
61 EGFR 1956
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
62 METTL21B  
Affinity Capture-MS Homo sapiens
63 KRT15 3866
Two-hybrid Homo sapiens
64 MAPK6  
Affinity Capture-MS Homo sapiens
65 TSPAN8 7103
Affinity Capture-MS Homo sapiens
66 RPA3 6119
Proximity Label-MS Homo sapiens
67 GPR45  
Affinity Capture-MS Homo sapiens
68 MTOR 2475
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
69 AQP3  
Affinity Capture-MS Homo sapiens
70 RPAP3 79657
Affinity Capture-MS Homo sapiens
71 HSPA4 3308
Affinity Capture-MS Homo sapiens
72 P2RY10  
Affinity Capture-MS Homo sapiens
73 HAX1  
Proximity Label-MS Homo sapiens
74 PEX3 8504
Proximity Label-MS Homo sapiens
75 TPM4 7171
Co-fractionation Homo sapiens
76 IRF3 3661
Affinity Capture-MS Homo sapiens
77 HUWE1 10075
Affinity Capture-MS Homo sapiens
78 CLN3 1201
Affinity Capture-MS Homo sapiens
79 HIF1A 3091
Affinity Capture-MS Homo sapiens
80 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
81 OPALIN  
Affinity Capture-MS Homo sapiens
82 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
83 MFSD4  
Affinity Capture-MS Homo sapiens
84 WDR92 116143
Affinity Capture-MS Homo sapiens
85 PIDD1  
Affinity Capture-MS Homo sapiens
86 HTR6  
Affinity Capture-MS Homo sapiens
87 CHRM3 1131
Affinity Capture-MS Homo sapiens
88 TTI2 80185
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
89 PLD3 23646
Affinity Capture-MS Homo sapiens
90 MAGED1 9500
Affinity Capture-MS Homo sapiens
91 C16orf72 29035
Affinity Capture-MS Homo sapiens
92 SMG1 23049
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 Ranbp2  
Affinity Capture-MS Mus musculus
94 BRD1 23774
Affinity Capture-MS Homo sapiens
95 PIH1D1  
Co-fractionation Homo sapiens
96 C9orf72  
Affinity Capture-MS Homo sapiens
97 AR 367
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TELO2 is involved
No pathways found





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