Gene description for STX18
Gene name syntaxin 18
Gene symbol STX18
Other names/aliases Ufe1
Species Homo sapiens
 Database cross references - STX18
ExoCarta ExoCarta_53407
Vesiclepedia VP_53407
Entrez Gene 53407
HGNC 15942
MIM 606046
UniProt Q9P2W9  
 STX18 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for STX18
Molecular Function
    SNAP receptor activity GO:0005484 IEA
    protein binding GO:0005515 IPI
    protein domain specific binding GO:0019904 IEA
Biological Process
    intracellular protein transport GO:0006886 IEA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IBA
    membrane fusion GO:0061025 IEA
    endoplasmic reticulum membrane organization GO:0090158 IMP
    positive regulation of organelle assembly GO:1902117 IMP
    positive regulation of ER to Golgi vesicle-mediated transport GO:1902953 IMP
    regulation of Golgi organization GO:1903358 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    SNARE complex GO:0031201 IBA
 Experiment description of studies that identified STX18 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for STX18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 VTI1B 10490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SNAP23 8773
Affinity Capture-MS Homo sapiens
7 METTL7A 25840
Proximity Label-MS Homo sapiens
8 NAPA 8775
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RACGAP1 29127
Affinity Capture-MS Homo sapiens
11 S100A6 6277
Affinity Capture-MS Homo sapiens
12 RNF25 64320
Affinity Capture-MS Homo sapiens
13 BNIP1 662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 LDOC1L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 HSD17B11 51170
Proximity Label-MS Homo sapiens
16 DNAJC25 548645
Proximity Label-MS Homo sapiens
17 PTPN1 5770
Proximity Label-MS Homo sapiens
18 STX4 6810
Proximity Label-MS Homo sapiens
19 B3GAT1  
Proximity Label-MS Homo sapiens
20 TBC1D20  
Affinity Capture-MS Homo sapiens
21 RINT1 60561
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
22 STX8 9482
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 STX7 8417
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 BLOC1S6  
Affinity Capture-MS Homo sapiens
25 TMEM201 199953
Affinity Capture-MS Homo sapiens
26 Cenpe  
Affinity Capture-MS Mus musculus
27 RPN2 6185
Proximity Label-MS Homo sapiens
28 STX6 10228
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CCDC47 57003
Affinity Capture-MS Homo sapiens
30 BET1 10282
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ZWINT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SSR1 6745
Proximity Label-MS Homo sapiens
33 FAM20C 56975
Affinity Capture-MS Homo sapiens
34 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 DVL2 1856
Affinity Capture-MS Homo sapiens
36 MARCKS 4082
Proximity Label-MS Homo sapiens
37 VTI1A 143187
Affinity Capture-MS Homo sapiens
38 KIAA1715 80856
Proximity Label-MS Homo sapiens
39 PXMP2  
Proximity Label-MS Homo sapiens
40 EGLN3  
Affinity Capture-MS Homo sapiens
41 SCFD1 23256
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 FUT8 2530
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 EMD 2010
Proximity Label-MS Homo sapiens
44 Rock1  
Affinity Capture-MS Mus musculus
45 BET1L 51272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 SNAP47 116841
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CHRNB2  
Affinity Capture-MS Homo sapiens
48 NUPR1  
Two-hybrid Homo sapiens
49 CCDC107  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 NAPG 8774
Affinity Capture-MS Homo sapiens
51 STX5 6811
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 TECR 9524
Affinity Capture-MS Homo sapiens
53 ELOVL5 60481
Proximity Label-MS Homo sapiens
54 SEC61B 10952
Proximity Label-MS Homo sapiens
55 SNAP29 9342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
57 REEP5 7905
Proximity Label-MS Homo sapiens
58 Cdc37 12539
Affinity Capture-MS Mus musculus
59 DISC1 27185
Two-hybrid Homo sapiens
60 BCAP31 10134
Proximity Label-MS Homo sapiens
61 NBAS 51594
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 TTYH1  
Affinity Capture-MS Homo sapiens
63 VAMP8 8673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 LRRC59 55379
Proximity Label-MS Homo sapiens
65 PANX1 24145
Proximity Label-MS Homo sapiens
66 LAMP1 3916
Proximity Label-MS Homo sapiens
67 Smad3  
Affinity Capture-MS Mus musculus
68 IFT57 55081
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 HSD3B7 80270
Proximity Label-MS Homo sapiens
70 STIM1 6786
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 FKBP8 23770
Proximity Label-MS Homo sapiens
72 TMEM9B 56674
Affinity Capture-MS Homo sapiens
73 Ect2  
Affinity Capture-MS Mus musculus
74 Vps4b 20479
Affinity Capture-MS Mus musculus
75 ZW10 9183
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 RPA3 6119
Proximity Label-MS Homo sapiens
77 B3GNT7  
Affinity Capture-MS Homo sapiens
78 ATP2A1 487
Proximity Label-MS Homo sapiens
79 CLEC12A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 RAB9A 9367
Proximity Label-MS Homo sapiens
81 ASPH 444
Affinity Capture-MS Homo sapiens
82 RPN1 6184
Proximity Label-MS Homo sapiens
83 CYP2C9  
Proximity Label-MS Homo sapiens
84 STX10 8677
Affinity Capture-MS Homo sapiens
85 NSF 4905
Affinity Capture-MS Homo sapiens
86 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
87 USE1 55850
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 STX16 8675
Affinity Capture-MS Homo sapiens
89 SCFD2 152579
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 TP53 7157
Negative Genetic Homo sapiens
91 VAMP3 9341
Affinity Capture-MS Homo sapiens
92 PGRMC1 10857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 CLUAP1 23059
Affinity Capture-MS Homo sapiens
94 EIF3I 8668
Affinity Capture-MS Homo sapiens
95 GOSR1 9527
Affinity Capture-MS Homo sapiens
96 TEX28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 Zw10  
Affinity Capture-MS Mus musculus
98 TPTE  
Affinity Capture-MS Homo sapiens
99 VAMP4 8674
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 C19orf25  
Affinity Capture-MS Homo sapiens
101 CHRM3 1131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 VAMP7 6845
Affinity Capture-MS Homo sapiens
103 ERGIC2 51290
Proximity Label-MS Homo sapiens
104 SEC62 7095
Proximity Label-MS Homo sapiens
105 STX3 6809
Affinity Capture-MS Homo sapiens
106 SPPL2B 56928
Affinity Capture-MS Homo sapiens
107 RAB7A 7879
Proximity Label-MS Homo sapiens
108 HNRNPA1L2 144983
Affinity Capture-MS Homo sapiens
109 VAMP5 10791
Affinity Capture-MS Homo sapiens
110 DNAJC1 64215
Proximity Label-MS Homo sapiens
111 KRAS 3845
Negative Genetic Homo sapiens
112 CKAP4 10970
Proximity Label-MS Homo sapiens
113 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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