Gene description for PEX1
Gene name peroxisomal biogenesis factor 1
Gene symbol PEX1
Other names/aliases PBD1A
PBD1B
ZWS
ZWS1
Species Homo sapiens
 Database cross references - PEX1
ExoCarta ExoCarta_5189
Entrez Gene 5189
HGNC 8850
MIM 602136
UniProt O43933  
 PEX1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PEX1
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IMP
    ATPase activity, coupled GO:0042623 IMP
    protein C-terminus binding GO:0008022 IPI
    protein complex binding GO:0032403 IDA
Biological Process
    protein import into peroxisome matrix GO:0016558 IMP
    peroxisome organization GO:0007031 IMP
    metabolic process GO:0008152 IMP
    protein targeting to peroxisome GO:0006625 IMP
    microtubule-based peroxisome localization GO:0060152 IMP
Subcellular Localization
    peroxisome GO:0005777 IDA
    peroxisomal membrane GO:0005778 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified PEX1 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for PEX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PEX1 is involved
No pathways found





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