Gene description for MTCH1
Gene name mitochondrial carrier 1
Gene symbol MTCH1
Other names/aliases CGI-64
PIG60
PSAP
SLC25A49
Species Homo sapiens
 Database cross references - MTCH1
ExoCarta ExoCarta_23787
Vesiclepedia VP_23787
Entrez Gene 23787
HGNC 17586
MIM 610449
UniProt Q9NZJ7  
 MTCH1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MTCH1
Molecular Function
    protein binding GO:0005515 IPI
    membrane insertase activity GO:0032977 IDA
Biological Process
    apoptotic process GO:0006915 IEA
    regulation of signal transduction GO:0009966 NAS
    positive regulation of apoptotic process GO:0043065 IBA
    positive regulation of apoptotic process GO:0043065 IEP
    protein insertion into mitochondrial outer membrane GO:0045040 IDA
    neuronal ion channel clustering GO:0045161 NAS
    positive regulation of cysteine-type endopeptidase activity GO:2001056 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IMP
    mitochondrial outer membrane GO:0005741 IEA
    membrane GO:0016020 IBA
 Experiment description of studies that identified MTCH1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MTCH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AFG3L2 10939
Proximity Label-MS Homo sapiens
2 CHMP7 91782
Proximity Label-MS Homo sapiens
3 YKT6 10652
Proximity Label-MS Homo sapiens
4 FAM73A  
Proximity Label-MS Homo sapiens
5 SPRTN  
Affinity Capture-MS Homo sapiens
6 IMMT 10989
Proximity Label-MS Homo sapiens
7 NBR1 4077
Proximity Label-MS Homo sapiens
8 RAB1A 5861
Proximity Label-MS Homo sapiens
9 PRKCD 5580
Proximity Label-MS Homo sapiens
10 NDUFS1 4719
Co-fractionation Homo sapiens
11 FBXL4 26235
Proximity Label-MS Homo sapiens
12 PSMD11 5717
Co-fractionation Homo sapiens
13 MARCH2  
Proximity Label-MS Homo sapiens
14 MFN1 55669
Proximity Label-MS Homo sapiens
15 NUDCD3 23386
Proximity Label-MS Homo sapiens
16 VPS13A 23230
Proximity Label-MS Homo sapiens
17 NABP2  
Affinity Capture-MS Homo sapiens
18 BNIP3L  
Proximity Label-MS Homo sapiens
19 RIC8A 60626
Affinity Capture-MS Homo sapiens
20 PTPN1 5770
Proximity Label-MS Homo sapiens
21 SLC22A9  
Affinity Capture-MS Homo sapiens
22 DUSP28  
Affinity Capture-MS Homo sapiens
23 PEX1 5189
Proximity Label-MS Homo sapiens
24 TOMM22 56993
Co-fractionation Homo sapiens
25 GSK3A 2931
Two-hybrid Homo sapiens
26 POTEE 445582
Proximity Label-MS Homo sapiens
27 ATP5D 513
Co-fractionation Homo sapiens
28 WDR41  
Proximity Label-MS Homo sapiens
29 SMCR8 140775
Proximity Label-MS Homo sapiens
30 DNAJC11 55735
Proximity Label-MS Homo sapiens
31 TIMMDC1  
Affinity Capture-MS Homo sapiens
32 TRABD 80305
Proximity Label-MS Homo sapiens
33 RAB3B 5865
Proximity Label-MS Homo sapiens
34 CLEC2B  
Affinity Capture-MS Homo sapiens
35 ABCD3 5825
Proximity Label-MS Homo sapiens
36 PSMC6 5706
Co-fractionation Homo sapiens
37 ARMCX3 51566
Proximity Label-MS Homo sapiens
38 EWSR1 2130
Co-fractionation Homo sapiens
39 VPS13D 55187
Proximity Label-MS Homo sapiens
40 PSMC2 5701
Co-fractionation Homo sapiens
41 LAMTOR3 8649
Co-fractionation Homo sapiens
42 PGRMC2 10424
Proximity Label-MS Homo sapiens
43 EXD2  
Proximity Label-MS Homo sapiens
44 TACSTD2 4070
Affinity Capture-MS Homo sapiens
45 BNIP3 664
Proximity Label-MS Homo sapiens
46 NDUFV1 4723
Co-fractionation Homo sapiens
47 TOMM40 10452
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
48 ATP6V0D1 9114
Co-fractionation Homo sapiens
49 NME2 4831
Proximity Label-MS Homo sapiens
50 SLC30A9 10463
Proximity Label-MS Homo sapiens
51 MECP2 4204
Affinity Capture-MS Homo sapiens
52 MAVS 57506
Proximity Label-MS Homo sapiens
53 USP7 7874
Affinity Capture-MS Homo sapiens
54 FAF2 23197
Proximity Label-MS Homo sapiens
55 FGFR1 2260
Affinity Capture-MS Homo sapiens
56 ATPAF1  
Proximity Label-MS Homo sapiens
57 PSMC3 5702
Co-fractionation Homo sapiens
58 SLC25A3 5250
Co-fractionation Homo sapiens
59 TDRKH  
Proximity Label-MS Homo sapiens
60 IMPDH1 3614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 VSIG4  
Affinity Capture-MS Homo sapiens
62 VSIG1  
Affinity Capture-MS Homo sapiens
63 ATAD3B 83858
Proximity Label-MS Homo sapiens
64 ATP5A1 498
Co-fractionation Homo sapiens
65 TRIM26 7726
Affinity Capture-MS Homo sapiens
66 CDC23 8697
Proximity Label-MS Homo sapiens
67 FUNDC2 65991
Proximity Label-MS Homo sapiens
68 MTFR1L 56181
Proximity Label-MS Homo sapiens
69 CHCHD3 54927
Proximity Label-MS Homo sapiens
70 ACOT2 10965
Proximity Label-MS Homo sapiens
71 PSMC1 5700
Co-fractionation Homo sapiens
72 ILVBL 10994
Co-fractionation Homo sapiens
73 PSMD14 10213
Co-fractionation Homo sapiens
74 TSPAN2 10100
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 SNAP47 116841
Proximity Label-MS Homo sapiens
76 LARP4 113251
Proximity Label-MS Homo sapiens
77 APOL2 23780
Proximity Label-MS Homo sapiens
78 PSMD2 5708
Co-fractionation Homo sapiens
79 SAR1B 51128
Proximity Label-MS Homo sapiens
80 MLX  
Proximity Label-MS Homo sapiens
81 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 GK  
Proximity Label-MS Homo sapiens
83 TACC1 6867
Proximity Label-MS Homo sapiens
84 MB21D1  
Proximity Label-MS Homo sapiens
85 RPN1 6184
Co-fractionation Homo sapiens
86 HECTD1 25831
Affinity Capture-MS Homo sapiens
87 HK2 3099
Proximity Label-MS Homo sapiens
88 INF2 64423
Proximity Label-MS Homo sapiens
89 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 ACSL4 2182
Proximity Label-MS Homo sapiens
91 VDAC2 7417
Co-fractionation Homo sapiens
92 DNM1L 10059
Proximity Label-MS Homo sapiens
93 RMDN3 55177
Proximity Label-MS Homo sapiens
94 ABCB7 22
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
95 SNAP29 9342
Proximity Label-MS Homo sapiens
96 ANAPC7 51434
Proximity Label-MS Homo sapiens
97 DUSP22  
Affinity Capture-MS Homo sapiens
98 CISD1 55847
Proximity Label-MS Homo sapiens
99 MTX3  
Proximity Label-MS Homo sapiens
100 C15orf48  
Affinity Capture-MS Homo sapiens
101 CYB5B 80777
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
102 GOLGA3 2802
Proximity Label-MS Homo sapiens
103 APLNR  
Two-hybrid Homo sapiens
104 GNB4 59345
Proximity Label-MS Homo sapiens
105 SDHA 6389
Co-fractionation Homo sapiens
106 SUGT1 10910
Proximity Label-MS Homo sapiens
107 MTX2 10651
Proximity Label-MS Homo sapiens
108 PRKAR2A 5576
Proximity Label-MS Homo sapiens
109 Rmdn3  
Affinity Capture-MS Mus musculus
110 STIP1 10963
Proximity Label-MS Homo sapiens
111 ATP5F1 515
Co-fractionation Homo sapiens
112 FKBP8 23770
Proximity Label-MS Homo sapiens
113 MYO19  
Proximity Label-MS Homo sapiens
114 ATP1B3 483
Co-fractionation Homo sapiens
115 MTFR1  
Proximity Label-MS Homo sapiens
116 MTFR2  
Proximity Label-MS Homo sapiens
117 PSMD7 5713
Co-fractionation Homo sapiens
118 EHBP1 23301
Proximity Label-MS Homo sapiens
119 OCIAD1 54940
Proximity Label-MS Homo sapiens
120 TOMM70A 9868
Proximity Label-MS Homo sapiens
121 SYP  
Affinity Capture-MS Homo sapiens
122 PEX14 5195
Proximity Label-MS Homo sapiens
123 PRKCQ 5588
Proximity Label-MS Homo sapiens
124 ATP5O 539
Co-fractionation Homo sapiens
125 PRPF19 27339
Co-fractionation Homo sapiens
126 NLRP3  
Affinity Capture-MS Homo sapiens
127 DNAJC7 7266
Proximity Label-MS Homo sapiens
128 TXNL1 9352
Proximity Label-MS Homo sapiens
129 LMF2 91289
Proximity Label-MS Homo sapiens
130 ATP1B1 481
Co-fractionation Homo sapiens
131 TGFA  
Affinity Capture-MS Homo sapiens
132 TCEB2 6923
Proximity Label-MS Homo sapiens
133 MFN2 9927
Proximity Label-MS Homo sapiens
134 DDRGK1 65992
Affinity Capture-MS Homo sapiens
135 CRYBG3  
Proximity Label-MS Homo sapiens
136 VDAC1 7416
Co-fractionation Homo sapiens
137 ARGLU1  
Proximity Label-MS Homo sapiens
138 AKAP1 8165
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
139 UBXN4 23190
Proximity Label-MS Homo sapiens
140 NDUFS2 4720
Proximity Label-MS Homo sapiens
141 ACBD5 91452
Proximity Label-MS Homo sapiens
142 TPM3 7170
Co-fractionation Homo sapiens
143 STUB1 10273
Proximity Label-MS Homo sapiens
144 NRG1 3084
Affinity Capture-MS Homo sapiens
145 MIEF1  
Proximity Label-MS Homo sapiens
146 DEPDC1B 55789
Proximity Label-MS Homo sapiens
147 FASN 2194
Co-fractionation Homo sapiens
148 ALDH3A2 224
Proximity Label-MS Homo sapiens
149 TRAK1 22906
Proximity Label-MS Homo sapiens
150 TOR1AIP2 163590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 ATP5L 10632
Co-fractionation Homo sapiens
152 PEX19 5824
Proximity Label-MS Homo sapiens
153 PDCL 5082
Proximity Label-MS Homo sapiens
154 DNAJA2 10294
Proximity Label-MS Homo sapiens
155 LRRC55  
Affinity Capture-MS Homo sapiens
156 EDEM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
157 NDUFS7 374291
Proximity Label-MS Homo sapiens
158 FKBP4 2288
Proximity Label-MS Homo sapiens
159 RHOT2 89941
Proximity Label-MS Homo sapiens
160 SLAMF1 6504
Affinity Capture-MS Homo sapiens
161 PRKAR2B 5577
Proximity Label-MS Homo sapiens
162 ATAD3A 55210
Proximity Label-MS Homo sapiens
163 MFF 56947
Proximity Label-MS Homo sapiens
164 UFL1 23376
Affinity Capture-MS Homo sapiens
165 USP30  
Proximity Label-MS Homo sapiens
166 SMIM12  
Proximity Label-MS Homo sapiens
167 BCL2L13 23786
Proximity Label-MS Homo sapiens
168 FGFR1OP2  
Co-fractionation Homo sapiens
169 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 HK1 3098
Proximity Label-MS Homo sapiens
171 RAB7A 7879
Proximity Label-MS Homo sapiens
172 ATP1A1 476
Co-fractionation Homo sapiens
173 CYB5R3 1727
Proximity Label-MS Homo sapiens
174 HSDL1 83693
Proximity Label-MS Homo sapiens
175 PEX5 5830
Proximity Label-MS Homo sapiens
176 HNRNPU 3192
Co-fractionation Homo sapiens
177 C9orf72  
Proximity Label-MS Homo sapiens
178 VDAC3 7419
Co-fractionation Homo sapiens
179 ST13 6767
Proximity Label-MS Homo sapiens
180 PSMC4 5704
Co-fractionation Homo sapiens
181 ARMC10 83787
Proximity Label-MS Homo sapiens
182 CACYBP 27101
Proximity Label-MS Homo sapiens
183 TOMM5  
Proximity Label-MS Homo sapiens
184 PSMD3 5709
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which MTCH1 is involved
No pathways found





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