Gene description for MTCH1
Gene name mitochondrial carrier 1
Gene symbol MTCH1
Other names/aliases CGI-64
PIG60
PSAP
SLC25A49
Species Homo sapiens
 Database cross references - MTCH1
ExoCarta ExoCarta_23787
Entrez Gene 23787
HGNC 17586
MIM 610449
UniProt Q9NZJ7  
 MTCH1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MTCH1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    transport GO:0006810 IEA
    regulation of signal transduction GO:0009966 NAS
    positive regulation of apoptotic process GO:0043065 IEP
    neuronal ion channel clustering GO:0045161 NAS
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IMP
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    intracellular GO:0005622 NAS
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrion GO:0005739 IMP
 Experiment description of studies that identified MTCH1 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MTCH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MTCH1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here