Gene description for ATAD3B
Gene name ATPase family, AAA domain containing 3B
Gene symbol ATAD3B
Other names/aliases AAA-TOB3
TOB3
Species Homo sapiens
 Database cross references - ATAD3B
ExoCarta ExoCarta_83858
Vesiclepedia VP_83858
Entrez Gene 83858
HGNC 24007
MIM 612317
UniProt Q5T9A4  
 ATAD3B identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ATAD3B
Molecular Function
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
Biological Process
    mitochondrion organization GO:0007005 IBA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IEA
    plasma membrane GO:0005886 TAS
    secretory granule membrane GO:0030667 TAS
    ficolin-1-rich granule membrane GO:0101003 TAS
 Experiment description of studies that identified ATAD3B in sEVs
1
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATAD3B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PMPCA 23203
Proximity Label-MS Homo sapiens
2 SPRTN  
Affinity Capture-MS Homo sapiens
3 MTCH1 23787
Proximity Label-MS Homo sapiens
4 LGR4 55366
Affinity Capture-MS Homo sapiens
5 MAGEA3  
Affinity Capture-MS Homo sapiens
6 SHC1 6464
Affinity Capture-MS Homo sapiens
7 BTF3 689
Affinity Capture-MS Homo sapiens
8 FBXO25  
Affinity Capture-MS Homo sapiens
9 NOP56 10528
Co-fractionation Homo sapiens
10 MTG2  
Proximity Label-MS Homo sapiens
11 MED13L 23389
Affinity Capture-MS Homo sapiens
12 KIF20A 10112
Affinity Capture-MS Homo sapiens
13 UBC 7316
Affinity Capture-MS Homo sapiens
14 SOX2  
Affinity Capture-MS Homo sapiens
15 CCDC90B  
Proximity Label-MS Homo sapiens
16 CD83  
Affinity Capture-MS Homo sapiens
17 USP36  
Affinity Capture-MS Homo sapiens
18 KIF23 9493
Affinity Capture-MS Homo sapiens
19 TRDN 10345
Affinity Capture-MS Homo sapiens
20 PRC1 9055
Affinity Capture-MS Homo sapiens
21 AGO3  
Affinity Capture-MS Homo sapiens
22 SSR1 6745
Co-fractionation Homo sapiens
23 PAGR1  
Affinity Capture-MS Homo sapiens
24 SURF1  
Proximity Label-MS Homo sapiens
25 EXD2  
Proximity Label-MS Homo sapiens
26 Cbx4  
Affinity Capture-MS Mus musculus
27 SRP68 6730
Co-fractionation Homo sapiens
28 NDUFAF1  
Affinity Capture-MS Homo sapiens
29 Wdr82  
Affinity Capture-MS Mus musculus
30 TFCP2 7024
Affinity Capture-MS Homo sapiens
31 MYCN  
Affinity Capture-MS Homo sapiens
32 VWA8 23078
Proximity Label-MS Homo sapiens
33 Spag5  
Affinity Capture-MS Mus musculus
34 DVL2 1856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 KIF14 9928
Affinity Capture-MS Homo sapiens
36 ATAD3A 55210
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
37 DYRK1B  
Affinity Capture-MS Homo sapiens
38 VSIG4  
Affinity Capture-MS Homo sapiens
39 KLF16  
Affinity Capture-MS Homo sapiens
40 APOO 79135
Proximity Label-MS Homo sapiens
41 AURKA 6790
Affinity Capture-MS Homo sapiens
42 NF2 4771
Affinity Capture-MS Homo sapiens
43 MTCH2 23788
Proximity Label-MS Homo sapiens
44 MED7  
Affinity Capture-MS Homo sapiens
45 COX15 1355
Proximity Label-MS Homo sapiens
46 USP11 8237
Affinity Capture-MS Homo sapiens
47 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 PNKP 11284
Affinity Capture-MS Homo sapiens
49 EIF2B5 8893
Affinity Capture-MS Homo sapiens
50 TUFM 7284
Proximity Label-MS Homo sapiens
51 DIABLO 56616
Proximity Label-MS Homo sapiens
52 CHMP4B 128866
Cross-Linking-MS (XL-MS) Homo sapiens
53 PBXIP1 57326
Affinity Capture-MS Homo sapiens
54 YAP1 10413
Affinity Capture-MS Homo sapiens
55 VCP 7415
Co-fractionation Homo sapiens
56 NTRK1 4914
Affinity Capture-MS Homo sapiens
57 CCDC109B 55013
Proximity Label-MS Homo sapiens
58 C20orf24  
Affinity Capture-MS Homo sapiens
59 PNMA2  
Affinity Capture-MS Homo sapiens
60 CLEC11A 6320
Affinity Capture-MS Homo sapiens
61 SMAD2 4087
Affinity Capture-MS Homo sapiens
62 S100B 6285
Affinity Capture-MS Homo sapiens
63 TRIM66  
Affinity Capture-MS Homo sapiens
64 RPN1 6184
Co-fractionation Homo sapiens
65 DNAJC30  
Proximity Label-MS Homo sapiens
66 Ksr1  
Affinity Capture-MS Mus musculus
67 COX4I1 1327
Proximity Label-MS Homo sapiens
68 DKK3 27122
Affinity Capture-MS Homo sapiens
69 ZBTB2 57621
Affinity Capture-MS Homo sapiens
70 SLC25A12 8604
Proximity Label-MS Homo sapiens
71 AIFM1 9131
Proximity Label-MS Homo sapiens
72 PINK1  
Affinity Capture-MS Homo sapiens
73 ECT2 1894
Affinity Capture-MS Homo sapiens
74 RLIM 51132
Affinity Capture-MS Homo sapiens
75 CUL3 8452
Affinity Capture-MS Homo sapiens
76 NR3C1 2908
Proximity Label-MS Homo sapiens
77 EGFR 1956
Affinity Capture-MS Homo sapiens
78 ATAD3C 219293
Cross-Linking-MS (XL-MS) Homo sapiens
79 FBXO6 26270
Affinity Capture-MS Homo sapiens
80 EPRS 2058
Co-fractionation Homo sapiens
81 MYC  
Affinity Capture-MS Homo sapiens
82 RIPK4  
Affinity Capture-MS Homo sapiens
83 C17orf80 55028
Proximity Label-MS Homo sapiens
84 AURKB 9212
Affinity Capture-MS Homo sapiens
85 PHB2 11331
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
86 PRKACA 5566
Affinity Capture-MS Homo sapiens
87 FGFR2 2263
Affinity Capture-MS Homo sapiens
88 SOAT1 6646
Affinity Capture-MS Homo sapiens
89 HHIPL1 84439
Affinity Capture-MS Homo sapiens
90 PPP2R1A 5518
Co-fractionation Homo sapiens
91 RPA3 6119
Proximity Label-MS Homo sapiens
92 CYC1 1537
Co-fractionation Homo sapiens
93 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
94 DDRGK1 65992
Affinity Capture-MS Homo sapiens
95 EIF2S2 8894
Co-fractionation Homo sapiens
96 NEUROG3  
Affinity Capture-MS Homo sapiens
97 FTSJ3 117246
Co-fractionation Homo sapiens
98 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
99 PPP4C 5531
Affinity Capture-MS Homo sapiens
100 ICT1 3396
Affinity Capture-MS Homo sapiens
101 CUL5 8065
Affinity Capture-MS Homo sapiens
102 PDHA1 5160
Affinity Capture-MS Homo sapiens
103 CDK15  
Affinity Capture-MS Homo sapiens
104 MLH1 4292
Affinity Capture-MS Homo sapiens
105 MAGEA9  
Affinity Capture-MS Homo sapiens
106 SFXN1 94081
Proximity Label-MS Homo sapiens
107 UFL1 23376
Affinity Capture-MS Homo sapiens
108 MED16 10025
Affinity Capture-MS Homo sapiens
109 SKAP1 8631
Affinity Capture-MS Homo sapiens
110 MED18  
Affinity Capture-MS Homo sapiens
111 MED21  
Affinity Capture-MS Homo sapiens
112 C19orf52  
Proximity Label-MS Homo sapiens
113 SLC25A51  
Proximity Label-MS Homo sapiens
114 SSSCA1 10534
Affinity Capture-MS Homo sapiens
115 CIT 11113
Affinity Capture-MS Homo sapiens
116 EPHA2 1969
Proximity Label-MS Homo sapiens
117 SERBP1 26135
Affinity Capture-MS Homo sapiens
118 Tnpo1 238799
Affinity Capture-MS Mus musculus
119 C9orf72  
Affinity Capture-MS Homo sapiens
120 METTL17  
Proximity Label-MS Homo sapiens
121 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 USP20  
Affinity Capture-MS Homo sapiens
123 ECSIT 51295
Affinity Capture-MS Homo sapiens
124 POLD1 5424
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATAD3B is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here