Gene description for PNKP
Gene name	polynucleotide kinase 3'-phosphatase
Gene symbol	PNKP
Other names/aliases	AOA4 EIEE10 MCSZ PNK
Species	Homo sapiens
Database cross references - PNKP
ExoCarta	ExoCarta_11284
Entrez Gene	11284
HGNC	9154
MIM	605610
UniProt	Q96T60
PNKP identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Hepatocytes	26054723
Thymus	23844026

Gene ontology annotations for PNKP

Molecular Function     purine nucleotide binding GO:0017076 NAS     ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity GO:0046404 IDA     nucleotide kinase activity GO:0019201 IDA     double-stranded DNA binding GO:0003690 TAS     protein binding GO:0005515 IPI     ATP binding GO:0005524 NAS     damaged DNA binding GO:0003684 NAS     polynucleotide 3'-phosphatase activity GO:0046403 IDA     endonuclease activity GO:0004519 NAS Biological Process     polynucleotide 3' dephosphorylation GO:0098506 IEA     DNA-dependent DNA replication GO:0006261 NAS     DNA damage response, detection of DNA damage GO:0042769 NAS     DNA 3' dephosphorylation involved in DNA repair GO:0098504 IBA     response to oxidative stress GO:0006979 IDA     nucleotide-excision repair, DNA damage removal GO:0000718 NAS     nucleic acid phosphodiester bond hydrolysis GO:0090305 NAS     DNA repair GO:0006281 TAS     nucleotide phosphorylation GO:0046939 IDA     dephosphorylation GO:0016311 IDA     base-excision repair GO:0006284 TAS     response to radiation GO:0009314 TAS Subcellular Localization     membrane GO:0016020 IDA     nucleoplasm GO:0005654 TAS     nucleus GO:0005634 IDA     nucleolus GO:0005730 IDA