Gene description for XRCC1
Gene name X-ray repair complementing defective repair in Chinese hamster cells 1
Gene symbol XRCC1
Other names/aliases RCC
Species Homo sapiens
 Database cross references - XRCC1
ExoCarta ExoCarta_7515
Vesiclepedia VP_7515
Entrez Gene 7515
HGNC 12828
MIM 194360
UniProt P18887  
 XRCC1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for XRCC1
Molecular Function
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    damaged DNA binding GO:0003684 IEA
Biological Process
    response to organic substance GO:0010033 IEA
    response to drug GO:0042493 IEA
    single strand break repair GO:0000012 IEA
    DNA repair GO:0006281 TAS
    hippocampus development GO:0021766 IEA
    response to hypoxia GO:0001666 IEA
    base-excision repair GO:0006284 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified XRCC1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for XRCC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PARP2  
Invitro Homo sapiens
Invivo Homo sapiens
2 PCNA 5111
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
3 APEX1 328
Invivo Homo sapiens
Two-hybrid Homo sapiens
4 OGG1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
5 NEIL1  
Reconstituted Complex Homo sapiens
6 APTX  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
7 POLB 5423
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
8 PARP1 142
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
9 LIG3 3980
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
10 TP53 7157
Affinity Capture-Western Homo sapiens
11 PNKP 11284
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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