Gene description for TDG
Gene name thymine-DNA glycosylase
Gene symbol TDG
Other names/aliases hTDG
Species Homo sapiens
 Database cross references - TDG
ExoCarta ExoCarta_6996
Entrez Gene 6996
HGNC 11700
MIM 601423
UniProt Q13569  
 TDG identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TDG
Molecular Function
    damaged DNA binding GO:0003684 TAS
    protein homodimerization activity GO:0042803 IDA
    protein domain specific binding GO:0019904 IEA
    SUMO binding GO:0032183 IEA
    structure-specific DNA binding GO:0043566 ISS
    pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263 IDA
    DNA N-glycosylase activity GO:0019104 IDA
    mismatched DNA binding GO:0030983 IDA
    RNA polymerase II transcription cofactor activity GO:0001104 IEA
    protein binding GO:0005515 IPI
    double-stranded DNA binding GO:0003690 IDA
    transcription factor binding GO:0008134 IEA
    protein kinase C binding GO:0005080 IEA
Biological Process
    transcription from RNA polymerase II promoter GO:0006366 IEA
    negative regulation of chromatin binding GO:0035562 IEA
    regulation of gene expression, epigenetic GO:0040029 TAS
    negative regulation of protein binding GO:0032091 IEA
    DNA repair GO:0006281 TAS
    embryo development GO:0009790 ISS
    cellular protein metabolic process GO:0044267 TAS
    DNA demethylation GO:0080111 ISS
    mismatch repair GO:0006298 IDA
    oxidative DNA demethylation GO:0035511 TAS
    chromatin modification GO:0016568 IEA
    base-excision repair GO:0006284 TAS
    depyrimidination GO:0045008 TAS
    base-excision repair, AP site formation GO:0006285 TAS
    gene expression GO:0010467 TAS
    protein sumoylation GO:0016925 TAS
    post-translational protein modification GO:0043687 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    plasma membrane GO:0005886 IDA
    PML body GO:0016605 IEA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified TDG in exosomes
Experiment ID 236
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TDG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TP53  
Two-hybrid Homo sapiens
2 ESR1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 RAD23B 5887
Affinity Capture-MS Homo sapiens
4 AR 367
Reconstituted Complex Homo sapiens
5 RXRA  
Reconstituted Complex Homo sapiens
6 VDR  
Reconstituted Complex Homo sapiens
7 RARA 5914
Reconstituted Complex Homo sapiens
8 NR3C1 2908
Reconstituted Complex Homo sapiens
9 PML  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
11 THRA  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
12 EP300 2033
Biochemical Activity Homo sapiens
13 SUMO1 7341
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
14 TP73  
Two-hybrid Homo sapiens
15 PGR  
Reconstituted Complex Homo sapiens
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