Gene description for RARA
Gene name	retinoic acid receptor, alpha
Gene symbol	RARA
Other names/aliases	NR1B1 RAR
Species	Homo sapiens
Database cross references - RARA
ExoCarta	ExoCarta_5914
Entrez Gene	5914
HGNC	9864
MIM	180240
UniProt	P10276
RARA identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for RARA

Molecular Function     protein kinase B binding GO:0043422 IPI     transcription corepressor activity GO:0003714 IDA     mRNA 5'-UTR binding GO:0048027 IEA     retinoic acid-responsive element binding GO:0044323 IDA     drug binding GO:0008144 IEA     enzyme binding GO:0019899 IPI     phosphatidylinositol 3-kinase regulator activity GO:0035014 IEA     receptor binding GO:0005102 IDA     steroid hormone receptor activity GO:0003707 IEA     sequence-specific DNA binding transcription factor activity GO:0003700 IDA     alpha-actinin binding GO:0051393 IPI     protein domain specific binding GO:0019904 IPI     zinc ion binding GO:0008270 IEA     protein heterodimerization activity GO:0046982 IDA     retinoic acid receptor activity GO:0003708 IDA     protein kinase A binding GO:0051018 IDA     translation repressor activity, nucleic acid binding GO:0000900 IEA     protein binding GO:0005515 IPI     transcription factor binding GO:0008134 IPI     transcription coactivator activity GO:0003713 IMP     chromatin DNA binding GO:0031490 IDA     RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IEA     retinoic acid binding GO:0001972 IDA Biological Process     signal transduction GO:0007165 IDA     steroid hormone mediated signaling pathway GO:0043401 IEA     positive regulation of binding GO:0051099 IMP     prostate gland development GO:0030850 IEA     response to vitamin A GO:0033189 IEA     response to cytokine GO:0034097 IEA     ureteric bud development GO:0001657 IEA     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     Sertoli cell fate commitment GO:0060010 IEA     embryonic camera-type eye development GO:0031076 IEA     positive regulation of neuron differentiation GO:0045666 IEA     negative regulation of cell proliferation GO:0008285 IEA     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IEA     neural tube closure GO:0001843 IEA     face development GO:0060324 IEA     positive regulation of cell proliferation GO:0008284 IMP     negative regulation of tumor necrosis factor production GO:0032720 IDA     negative regulation of cartilage development GO:0061037 IEA     negative regulation of translational initiation GO:0045947 IEA     female pregnancy GO:0007565 IEA     retinoic acid receptor signaling pathway GO:0048384 IMP     apoptotic cell clearance GO:0043277 IMP     germ cell development GO:0007281 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     gene expression GO:0010467 TAS     response to estradiol GO:0032355 IEA     negative regulation of apoptotic process GO:0043066 IEA     positive regulation of transcription, DNA-templated GO:0045893 IMP     negative regulation of granulocyte differentiation GO:0030853 IDA     trachea cartilage development GO:0060534 IEA     protein phosphorylation GO:0006468 IMP     negative regulation of transcription, DNA-templated GO:0045892 IDA     spermatogenesis GO:0007283 IEA     cellular response to retinoic acid GO:0071300 IDA     negative regulation of interferon-gamma production GO:0032689 IDA     positive regulation of T-helper 2 cell differentiation GO:0045630 IDA     outflow tract septum morphogenesis GO:0003148 IEA     cellular response to estrogen stimulus GO:0071391 IDA     positive regulation of interleukin-4 production GO:0032753 IDA     positive regulation of interleukin-13 production GO:0032736 IDA     response to ethanol GO:0045471 IEA     chondroblast differentiation GO:0060591 IEA     regulation of myelination GO:0031641 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     positive regulation of protein kinase B signaling GO:0051897 IEA     limb development GO:0060173 IEA     glandular epithelial cell development GO:0002068 IEA     positive regulation of interleukin-5 production GO:0032754 IDA     growth plate cartilage development GO:0003417 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     multicellular organism growth GO:0035264 IEA     positive regulation of cell cycle GO:0045787 IMP     ventricular cardiac muscle cell differentiation GO:0055012 IEA     response to retinoic acid GO:0032526 IMP     regulation of synaptic plasticity GO:0048167 IEA     liver development GO:0001889 IEA     cellular response to lipopolysaccharide GO:0071222 IEA     regulation of phosphatidylinositol 3-kinase activity GO:0043551 IEA Subcellular Localization     nuclear chromatin GO:0000790 IDA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     cell surface GO:0009986 IC     actin cytoskeleton GO:0015629 IDA     perinuclear region of cytoplasm GO:0048471 IEA     neuronal cell body GO:0043025 IEA     dendrite GO:0030425 IEA     cytoplasm GO:0005737 IDA