Gene description for HIST1H2AA
Gene name histone cluster 1, H2aa
Gene symbol HIST1H2AA
Other names/aliases H2AA
H2AFR
bA317E16.2
Species Homo sapiens
 Database cross references - HIST1H2AA
ExoCarta ExoCarta_221613
Entrez Gene 221613
HGNC 18729
MIM 613499
UniProt Q96QV6  
 HIST1H2AA identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for HIST1H2AA
Molecular Function
    DNA binding GO:0003677 IEA
    protein heterodimerization activity GO:0046982 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IDA
    nucleosome GO:0000786 IEA
 Experiment description of studies that identified HIST1H2AA in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for HIST1H2AA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HIST1H2AA is involved
PathwayEvidenceSource
HATs acetylate histones TAS Reactome
HDACs deacetylate histones TAS Reactome
RMTs methylate histone arginines TAS Reactome





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