Gene description for LOC102724334
Gene name histone H2B type F-S-like
Gene symbol LOC102724334
Other names/aliases -
Species Homo sapiens
 Database cross references - LOC102724334
ExoCarta ExoCarta_102724334
Vesiclepedia VP_102724334
Entrez Gene 102724334
UniProt P57053  
 LOC102724334 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for LOC102724334
 Experiment description of studies that identified LOC102724334 in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for LOC102724334
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST1H2AI 8329
Cross-Linking-MS (XL-MS) Homo sapiens
2 HIST1H2AA 221613
Cross-Linking-MS (XL-MS) Homo sapiens
3 HMGN3  
Cross-Linking-MS (XL-MS) Homo sapiens
4 H2AFJ 55766
Cross-Linking-MS (XL-MS) Homo sapiens
5 HNRNPD 3184
Affinity Capture-MS Homo sapiens
6 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
7 HIST2H2AB 317772
Cross-Linking-MS (XL-MS) Homo sapiens
8 HMGN4  
Cross-Linking-MS (XL-MS) Homo sapiens
9 HIST1H2AC 8334
Cross-Linking-MS (XL-MS) Homo sapiens
10 TARBP1 6894
Cross-Linking-MS (XL-MS) Homo sapiens
11 KIF14 9928
Affinity Capture-MS Homo sapiens
12 KIF20A 10112
Affinity Capture-MS Homo sapiens
13 TEX35  
Cross-Linking-MS (XL-MS) Homo sapiens
14 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
15 CHMP4C 92421
Affinity Capture-MS Homo sapiens
16 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
17 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
18 KNOP1 400506
Cross-Linking-MS (XL-MS) Homo sapiens
19 YWHAZ 7534
Cross-Linking-MS (XL-MS) Homo sapiens
20 UBC 7316
Cross-Linking-MS (XL-MS) Homo sapiens
21 SFMBT2  
Cross-Linking-MS (XL-MS) Homo sapiens
22 HMGN2 3151
Cross-Linking-MS (XL-MS) Homo sapiens
23 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
24 SKAP2 8935
Cross-Linking-MS (XL-MS) Homo sapiens
25 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
26 DPPA2  
Cross-Linking-MS (XL-MS) Homo sapiens
27 UBB 7314
Cross-Linking-MS (XL-MS) Homo sapiens
28 TOP2A 7153
Cross-Linking-MS (XL-MS) Homo sapiens
29 SYNPO 11346
Cross-Linking-MS (XL-MS) Homo sapiens
30 ADAMTS12 81792
Cross-Linking-MS (XL-MS) Homo sapiens
31 HIST1H2AH 85235
Cross-Linking-MS (XL-MS) Homo sapiens
32 PCLO 27445
Cross-Linking-MS (XL-MS) Homo sapiens
33 EIF4B 1975
Cross-Linking-MS (XL-MS) Homo sapiens
34 DUOX2 50506
Cross-Linking-MS (XL-MS) Homo sapiens
35 MYBPC1  
Cross-Linking-MS (XL-MS) Homo sapiens
36 TNN 63923
Cross-Linking-MS (XL-MS) Homo sapiens
37 PRC1 9055
Affinity Capture-MS Homo sapiens
38 FAM47B  
Cross-Linking-MS (XL-MS) Homo sapiens
39 HMGA1 3159
Cross-Linking-MS (XL-MS) Homo sapiens
40 ZNF474  
Cross-Linking-MS (XL-MS) Homo sapiens
41 HIST1H2AJ 8331
Cross-Linking-MS (XL-MS) Homo sapiens
42 HIST2H2AC 8338
Cross-Linking-MS (XL-MS) Homo sapiens
43 HCLS1 3059
Cross-Linking-MS (XL-MS) Homo sapiens
44 H2AFX 3014
Cross-Linking-MS (XL-MS) Homo sapiens
45 HIST1H2BA 255626
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which LOC102724334 is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Defective pyroptosis TAS Reactome
Deposition of new CENPA-containing nucleosomes at the centromere TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA methylation IEA Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Metabolism of proteins TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
NoRC negatively regulates rRNA expression TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Processing of DNA double-strand break ends TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Replacement of protamines by nucleosomes in the male pronucleus IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
Telomere Maintenance TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome





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