Gene description for DUOX2
Gene name dual oxidase 2
Gene symbol DUOX2
Other names/aliases LNOX2
NOXEF2
P138-TOX
TDH6
THOX2
Species Homo sapiens
 Database cross references - DUOX2
ExoCarta ExoCarta_50506
Entrez Gene 50506
HGNC 13273
MIM 606759
UniProt Q9NRD8  
 DUOX2 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for DUOX2
Molecular Function
    NAD(P)H oxidase activity GO:0016174 IMP
    peroxidase activity GO:0004601 IEA
    heme binding GO:0020037 IEA
    calcium ion binding GO:0005509 IDA
Biological Process
    hydrogen peroxide catabolic process GO:0042744 IEA
    cuticle development GO:0042335 ISS
    oxidation-reduction process GO:0055114 TAS
    fertilization GO:0009566 IEA
    response to cAMP GO:0051591 ISS
    hormone biosynthetic process GO:0042446 IEA
    bone mineralization GO:0030282 IEA
    thyroid hormone generation GO:0006590 IEA
    inner ear development GO:0048839 IEA
    cytokine-mediated signaling pathway GO:0019221 ISS
    multicellular organism growth GO:0035264 IEA
    response to virus GO:0009615 IDA
    thyroid gland development GO:0030878 IEA
    adenohypophysis morphogenesis GO:0048855 IEA
    response to oxidative stress GO:0006979 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified DUOX2 in exosomes
1
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for DUOX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DUOX2 is involved
No pathways found





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