Gene description for DUOX2
Gene name	dual oxidase 2
Gene symbol	DUOX2
Other names/aliases	LNOX2 NOXEF2 P138-TOX TDH6 THOX2
Species	Homo sapiens
Database cross references - DUOX2
ExoCarta	ExoCarta_50506
Vesiclepedia	VP_50506
Entrez Gene	50506
HGNC	13273
MIM	606759
UniProt	Q9NRD8
DUOX2 identified in sEVs derived from the following tissue/cell type
Saliva	19199708

Gene ontology annotations for DUOX2

Molecular Function     peroxidase activity GO:0004601 IEA     calcium ion binding GO:0005509 IDA     protein binding GO:0005515 IPI     NAD(P)H oxidase H2O2-forming activity GO:0016174 IDA     NAD(P)H oxidase H2O2-forming activity GO:0016174 IMP     NAD(P)H oxidase H2O2-forming activity GO:0016174 TAS     superoxide-generating NAD(P)H oxidase activity GO:0016175 IBA     heme binding GO:0020037 IEA     NADH oxidase H202-forming activity GO:0106293 IEA     NADPH oxidase H202-forming activity GO:0106294 IEA Biological Process     thyroid hormone generation GO:0006590 IEA     thyroid hormone generation GO:0006590 TAS     defense response GO:0006952 IBA     response to oxidative stress GO:0006979 IEA     response to virus GO:0009615 IDA     cytokine-mediated signaling pathway GO:0019221 IDA     cytokine-mediated signaling pathway GO:0019221 ISS     cuticle development GO:0042335 ISS     hormone biosynthetic process GO:0042446 IEA     superoxide anion generation GO:0042554 IBA     superoxide anion generation GO:0042554 IGI     hydrogen peroxide catabolic process GO:0042744 IEA     hydrogen peroxide biosynthetic process GO:0050665 IGI     response to cAMP GO:0051591 IDA     response to cAMP GO:0051591 ISS     positive regulation of wound healing GO:0090303 IGI     cellular oxidant detoxification GO:0098869 IEA     positive regulation of cell motility GO:2000147 IGI Subcellular Localization     endoplasmic reticulum GO:0005783 IDA     cytosol GO:0005829 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IGI     plasma membrane GO:0005886 TAS     cell surface GO:0009986 IGI     apical plasma membrane GO:0016324 IEA     cell leading edge GO:0031252 IGI     NADPH oxidase complex GO:0043020 IBA     apical part of cell GO:0045177 IDA     extracellular exosome GO:0070062 HDA     anchoring junction GO:0070161 IEA