Gene description for RXRB
Gene name retinoid X receptor, beta
Gene symbol RXRB
Other names/aliases DAUDI6
H-2RIIBP
NR2B2
RCoR-1
Species Homo sapiens
 Database cross references - RXRB
ExoCarta ExoCarta_6257
Vesiclepedia VP_6257
Entrez Gene 6257
HGNC 10478
MIM 180246
UniProt P28702  
 RXRB identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RXRB
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    nuclear steroid receptor activity GO:0003707 IEA
    nuclear receptor activity GO:0004879 IBA
    nuclear receptor activity GO:0004879 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    retinoic acid-responsive element binding GO:0044323 IBA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    nervous system development GO:0007399 IBA
    hormone-mediated signaling pathway GO:0009755 ISS
    cell differentiation GO:0030154 IBA
    positive regulation of bone mineralization GO:0030501 NAS
    mRNA transcription by RNA polymerase II GO:0042789 ISS
    steroid hormone receptor signaling pathway GO:0043401 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    retinoic acid receptor signaling pathway GO:0048384 IBA
    positive regulation of vitamin D receptor signaling pathway GO:0070564 ISS
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 IDA
    RNA polymerase II transcription regulator complex GO:0090575 IBA
    RNA polymerase II transcription regulator complex GO:0090575 IPI
    RNA polymerase II transcription regulator complex GO:0090575 ISS
 Experiment description of studies that identified RXRB in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RXRB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TXLNA 200081
Affinity Capture-MS Homo sapiens
2 ADRBK1 156
Affinity Capture-MS Homo sapiens
3 CACNA1B 774
Reconstituted Complex Homo sapiens
4 MCAT 27349
Affinity Capture-MS Homo sapiens
5 VDR  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
6 RARA 5914
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 SPOP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 PTMS 5763
Reconstituted Complex Homo sapiens
9 MAP4 4134
Two-hybrid Homo sapiens
10 NR4A2  
Two-hybrid Homo sapiens
11 Cebpb  
Affinity Capture-Western Rattus norvegicus
12 THRB 7068
Two-hybrid Homo sapiens
13 NCOA1  
Two-hybrid Homo sapiens
14 ZDHHC12  
Two-hybrid Homo sapiens
15 PPARG 5468
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
16 FLYWCH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 WRAP53  
Affinity Capture-MS Homo sapiens
18 CUL3 8452
Affinity Capture-MS Homo sapiens
19 NR3C1 2908
Two-hybrid Homo sapiens
20 RARB  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 AKAP13 11214
Reconstituted Complex Homo sapiens
22 MRPS10 55173
Affinity Capture-MS Homo sapiens
23 NR1H3  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 NR1I2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
25 POLR3F  
Affinity Capture-MS Homo sapiens
26 CCNK  
Affinity Capture-MS Homo sapiens
27 NR1H4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 GTF2H1 2965
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
29 SPOPL  
Two-hybrid Homo sapiens
30 PPARA  
Affinity Capture-Western Homo sapiens
31 AFF4 27125
Affinity Capture-MS Homo sapiens
32 PPARD  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
33 NR2C2  
Two-hybrid Homo sapiens
34 C2CD5 9847
Affinity Capture-MS Homo sapiens
35 NRIP1 8204
Reconstituted Complex Homo sapiens
36 C12orf10 60314
Two-hybrid Homo sapiens
37 CDC42BPB 9578
Affinity Capture-MS Homo sapiens
38 NR1H2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
39 DUPD1  
Affinity Capture-MS Homo sapiens
40 RARG  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
41 CDC5L 988
Affinity Capture-MS Homo sapiens
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