Gene description for C2CD5
Gene name C2 calcium-dependent domain containing 5
Gene symbol C2CD5
Other names/aliases CDP138
KIAA0528
Species Homo sapiens
 Database cross references - C2CD5
ExoCarta ExoCarta_9847
Entrez Gene 9847
HGNC 29062
UniProt Q86YS7  
 C2CD5 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for C2CD5
Molecular Function
    calcium-dependent phospholipid binding GO:0005544 IDA
    calcium ion binding GO:0005509 IDA
Biological Process
    insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038028 ISS
    protein localization to plasma membrane GO:0072659 IEA
    vesicle fusion GO:0006906 IEA
    positive regulation of protein targeting to membrane GO:0090314 IMP
    positive regulation of glucose transport GO:0010828 ISS
    positive regulation of vesicle fusion GO:0031340 IMP
    cellular response to insulin stimulus GO:0032869 IDA
    intracellular protein transmembrane transport GO:0065002 IMP
    positive regulation of glucose import in response to insulin stimulus GO:2001275 IEA
    membrane organization GO:0061024 TAS
Subcellular Localization
    microtubule organizing center GO:0005815 IDA
    cytoplasmic vesicle membrane GO:0030659 IDA
    plasma membrane GO:0005886 IDA
    cell cortex GO:0005938 IDA
    cytoplasm GO:0005737 IDA
    ruffle membrane GO:0032587 IDA
 Experiment description of studies that identified C2CD5 in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for C2CD5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FIBP  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which C2CD5 is involved
PathwayEvidenceSource
Translocation of GLUT4 to the plasma membrane TAS Reactome





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