Gene description for IL13
Gene name interleukin 13
Gene symbol IL13
Other names/aliases IL-13
P600
Species Homo sapiens
 Database cross references - IL13
ExoCarta ExoCarta_3596
Vesiclepedia VP_3596
Entrez Gene 3596
HGNC 5973
MIM 147683
UniProt P35225  
 IL13 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IL13
Molecular Function
    protein binding GO:0005515 IPI
    cytokine activity GO:0005125 IEA
    interleukin-13 receptor binding GO:0005144 IBA
Biological Process
    positive regulation of connective tissue growth factor production GO:0032723 IEA
    response to ethanol GO:0045471 IEA
    immune response GO:0006955 IEA
    negative regulation of lung ciliated cell differentiation GO:1901247 NAS
    negative regulation of neuron death GO:1901215 IEA
    regulation of proton transport GO:0010155 IEA
    negative regulation of complement-dependent cytotoxicity GO:1903660 IMP
    negative regulation of endothelial cell apoptotic process GO:2000352 IMP
    positive regulation of protein secretion GO:0050714 IEA
    movement of cell or subcellular component GO:0006928 TAS
    microglial cell activation GO:0001774 IEA
    negative regulation of transforming growth factor beta production GO:0071635 IEA
    positive regulation of immunoglobulin production GO:0002639 IBA
    positive regulation of tyrosine phosphorylation of Stat6 protein GO:0042526 IEA
    cellular response to mechanical stimulus GO:0071260 IEA
    positive regulation of lung goblet cell differentiation GO:1901251 NAS
    cell-cell signaling GO:0007267 IC
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA
    positive regulation of B cell proliferation GO:0030890 IBA
    inflammatory response GO:0006954 IEA
    response to lipopolysaccharide GO:0032496 IEA
    negative regulation of NAD(P)H oxidase activity GO:0033861 IEA
    cellular response to cytokine stimulus GO:0071345 IBA
    positive regulation of mast cell degranulation GO:0043306 IBA
    response to nicotine GO:0035094 IEA
    positive regulation of macrophage activation GO:0043032 IBA
    positive regulation of pancreatic stellate cell proliferation GO:2000231 IEA
    signal transduction GO:0007165 NAS
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
Subcellular Localization
    extracellular space GO:0005615 ISS
    cytoplasm GO:0005737 IEA
    external side of plasma membrane GO:0009897 IEA
    extracellular region GO:0005576 IDA
 Experiment description of studies that identified IL13 in exosomes
1
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IL13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VCAM1 7412
Invitro Homo sapiens
2 IL13RA2 3598
Invitro Homo sapiens
Invivo Homo sapiens
3 IL4R  
Invivo Homo sapiens
4 IL13RA1  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which IL13 is involved
No pathways found





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