Gene description for CACNA1B
Gene name calcium channel, voltage-dependent, N type, alpha 1B subunit
Gene symbol CACNA1B
Other names/aliases BIII
CACNL1A5
CACNN
Cav2.2
DYT23
Species Homo sapiens
 Database cross references - CACNA1B
ExoCarta ExoCarta_774
Entrez Gene 774
HGNC 1389
MIM 601012
UniProt Q00975  
 CACNA1B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CACNA1B
Molecular Function
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 IEA
    voltage-gated calcium channel activity GO:0005245 TAS
    ATP binding GO:0005524 IEA
    high voltage-gated calcium channel activity GO:0008331 IBA
    protein C-terminus binding GO:0008022 IPI
Biological Process
    regulation of blood pressure GO:0008217 IEA
    synaptic transmission GO:0007268 TAS
    regulation of calcium ion transport GO:0051924 IEA
    ion transmembrane transport GO:0034220 IBA
    calcium ion transmembrane transport GO:0070588 IEA
    membrane depolarization GO:0051899 TAS
    calcium ion transport GO:0006816 IBA
    neurotransmitter secretion GO:0007269 IEA
    calcium ion import GO:0070509 IBA
    regulation of ion transmembrane transport GO:0034765 IEA
    response to pain GO:0048265 IEA
    transport GO:0006810 TAS
    locomotory behavior GO:0007626 IEA
    regulation of heart contraction GO:0008016 IEA
    membrane depolarization during action potential GO:0086010 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    neuronal cell body GO:0043025 IEA
    dendrite GO:0030425 IEA
    voltage-gated calcium channel complex GO:0005891 IEA
 Experiment description of studies that identified CACNA1B in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CACNA1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNAO1 2775
Reconstituted Complex Homo sapiens
2 CACNB3  
Invitro Homo sapiens
3 PDLIM5 10611
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CACNA1B is involved
PathwayEvidenceSource
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels TAS Reactome





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