Gene description for CAMK2A
Gene name calcium/calmodulin-dependent protein kinase II alpha
Gene symbol CAMK2A
Other names/aliases CAMKA
Species Homo sapiens
 Database cross references - CAMK2A
ExoCarta ExoCarta_815
Vesiclepedia VP_815
Entrez Gene 815
HGNC 1460
MIM 114078
UniProt Q9UQM7  
 CAMK2A identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CAMK2A
Molecular Function
    protein homodimerization activity GO:0042803 IPI
    ATP binding GO:0005524 IEA
    glutamate receptor binding GO:0035254 ISS
    calmodulin binding GO:0005516 IPI
    kinase activity GO:0016301 IDA
    protein serine/threonine kinase activity GO:0004674 ISS
    protein binding GO:0005515 IPI
    calmodulin-dependent protein kinase activity GO:0004683 IEA
Biological Process
    positive regulation of cardiac muscle cell apoptotic process GO:0010666 ISS
    protein autophosphorylation GO:0046777 ISS
    response to ischemia GO:0002931 ISS
    regulation of cellular response to heat GO:1900034 TAS
    synaptic transmission GO:0007268 TAS
    regulation of neurotransmitter secretion GO:0046928 ISS
    regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 ISS
    angiotensin-activated signaling pathway GO:0038166 IDA
    positive regulation of calcium ion transport GO:0051928 ISS
    calcium ion transport GO:0006816 ISS
    protein phosphorylation GO:0006468 IDA
    cytokine-mediated signaling pathway GO:0019221 TAS
    G1/S transition of mitotic cell cycle GO:0000082 ISS
    cellular response to heat GO:0034605 TAS
    interferon-gamma-mediated signaling pathway GO:0060333 TAS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    peptidyl-serine phosphorylation GO:0018105 ISS
    regulation of neuronal synaptic plasticity GO:0048168 ISS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    mitochondrion GO:0005739 ISS
    endocytic vesicle membrane GO:0030666 TAS
    nucleus GO:0005634 IDA
    presynaptic membrane GO:0042734 IEA
    cytosol GO:0005829 TAS
    nucleoplasm GO:0005654 TAS
    cell junction GO:0030054 IEA
 Experiment description of studies that identified CAMK2A in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CAMK2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK5R1  
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 RIMS1  
Biochemical Activity Homo sapiens
3 CAMK2D 817
Affinity Capture-MS Homo sapiens
4 CALM3 808
Affinity Capture-MS Homo sapiens
5 ITPKA  
Invivo Homo sapiens
6 DLG1 1739
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
7 GRIN2B  
Reconstituted Complex Homo sapiens
8 ATF1  
Biochemical Activity Homo sapiens
9 PARK2  
Affinity Capture-Western Homo sapiens
10 CAMK2B 816
Affinity Capture-MS Homo sapiens
11 DLG3 1741
Affinity Capture-MS Homo sapiens
12 CREB1  
Biochemical Activity Homo sapiens
13 CHMP5 51510
Affinity Capture-MS Homo sapiens
14 LRRC7 57554
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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