Gene description for BAP1
Gene name BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Gene symbol BAP1
Other names/aliases HUCEP-13
UCHL2
hucep-6
Species Homo sapiens
 Database cross references - BAP1
ExoCarta ExoCarta_8314
Entrez Gene 8314
HGNC 950
MIM 603089
UniProt Q92560  
 BAP1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for BAP1
Molecular Function
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 NAS
    chromatin binding GO:0003682 IDA
    ubiquitin-specific protease activity GO:0004843 IDA
Biological Process
    protein deubiquitination GO:0016579 IDA
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    regulation of cell growth GO:0001558 IMP
    monoubiquitinated protein deubiquitination GO:0035520 IDA
    regulation of cell cycle GO:0051726 IMP
    negative regulation of cell proliferation GO:0008285 TAS
    ubiquitin-dependent protein catabolic process GO:0006511 IEA
    monoubiquitinated histone H2A deubiquitination GO:0035522 IDA
    protein K48-linked deubiquitination GO:0071108 IMP
    cellular protein modification process GO:0006464 NAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    PR-DUB complex GO:0035517 IDA
 Experiment description of studies that identified BAP1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for BAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRCA1 672
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which BAP1 is involved
No pathways found





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