Gene description for NPHP3
Gene name nephronophthisis 3 (adolescent)
Gene symbol NPHP3
Other names/aliases CFAP31
MKS7
NPH3
RHPD
RHPD1
SLSN3
Species Homo sapiens
 Database cross references - NPHP3
ExoCarta ExoCarta_27031
Vesiclepedia VP_27031
Entrez Gene 27031
HGNC 7907
MIM 608002
UniProt Q7Z494  
 NPHP3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NPHP3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    convergent extension involved in gastrulation GO:0060027 IGI
    determination of left/right symmetry GO:0007368 IMP
    kidney morphogenesis GO:0060993 IMP
    epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 IC
    heart looping GO:0001947 IMP
    determination of intestine left/right asymmetry GO:0071908 IMP
    determination of stomach left/right asymmetry GO:0071909 IMP
    determination of pancreatic left/right asymmetry GO:0035469 IMP
    ureter development GO:0072189 IMP
    cilium morphogenesis GO:0060271 ISS
    kidney development GO:0001822 IMP
    maintenance of organ identity GO:0048496 IMP
    Wnt signaling pathway GO:0016055 IEA
    regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000095 ISS
    determination of liver left/right asymmetry GO:0071910 IMP
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    regulation of planar cell polarity pathway involved in neural tube closure GO:2000167 IC
    lung development GO:0030324 IMP
    organelle organization GO:0006996 TAS
    photoreceptor cell maintenance GO:0045494 IMP
    atrial septum development GO:0003283 IMP
Subcellular Localization
    cytosol GO:0005829 TAS
    primary cilium GO:0072372 TAS
    cilium GO:0005929 IDA
 Experiment description of studies that identified NPHP3 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NPHP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NPHP1  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which NPHP3 is involved
PathwayEvidenceSource
Trafficking of myristoylated proteins to the cilium TAS Reactome





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