Gene description for PDE8A
Gene name phosphodiesterase 8A
Gene symbol PDE8A
Other names/aliases HsT19550
Species Homo sapiens
 Database cross references - PDE8A
ExoCarta ExoCarta_5151
Entrez Gene 5151
HGNC 8793
MIM 602972
UniProt O60658  
 PDE8A identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PDE8A
Molecular Function
    metal ion binding GO:0046872 IEA
    signal transducer activity GO:0004871 IEA
    3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 IEA
    3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 NAS
Biological Process
    cyclic nucleotide metabolic process GO:0009187 NAS
    regulation of transcription, DNA-templated GO:0006355 IEA
    cAMP catabolic process GO:0006198 IEA
    phosphorelay signal transduction system GO:0000160 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PDE8A in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PDE8A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PDE8A is involved
PathwayEvidenceSource
G alpha (s) signalling events TAS Reactome





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