Gene description for FDX1
Gene name ferredoxin 1
Gene symbol FDX1
Other names/aliases ADX
FDX
LOH11CR1D
Species Homo sapiens
 Database cross references - FDX1
ExoCarta ExoCarta_2230
Vesiclepedia VP_2230
Entrez Gene 2230
HGNC 3638
MIM 103260
UniProt P10109  
 FDX1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for FDX1
Molecular Function
    iron ion binding GO:0005506 TAS
    electron transfer activity GO:0009055 IBA
    electron transfer activity GO:0009055 IDA
    2 iron, 2 sulfur cluster binding GO:0051537 IDA
Biological Process
    steroid biosynthetic process GO:0006694 IEA
    cholesterol metabolic process GO:0008203 IDA
    electron transport chain GO:0022900 IBA
    hormone biosynthetic process GO:0042446 IDA
    cellular response to cAMP GO:0071320 IEA
    P450-containing electron transport chain GO:0140647 IEA
    cellular response to forskolin GO:1904322 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 ISS
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified FDX1 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for FDX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTP1 2950
Co-fractionation Homo sapiens
2 NDUFAB1 4706
Co-fractionation Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 CS 1431
Proximity Label-MS Homo sapiens
5 CLIC1 1192
Co-fractionation Homo sapiens
6 TSFM 10102
Proximity Label-MS Homo sapiens
7 GLOD4 51031
Co-fractionation Homo sapiens
8 PGLS 25796
Co-fractionation Homo sapiens
9 SOD1 6647
Co-fractionation Homo sapiens
10 Lima1  
Affinity Capture-MS Mus musculus
11 CPOX 1371
Co-fractionation Homo sapiens
12 GPI 2821
Co-fractionation Homo sapiens
13 FEN1 2237
Co-fractionation Homo sapiens
14 MDH2 4191
Proximity Label-MS Homo sapiens
15 GCSH 2653
Co-fractionation Homo sapiens
16 Prdx1 18477
Affinity Capture-MS Mus musculus
17 ATP5A1 498
Co-fractionation Homo sapiens
18 CAPZA2 830
Affinity Capture-MS Homo sapiens
19 ARCN1 372
Co-fractionation Homo sapiens
20 COX8A  
Proximity Label-MS Homo sapiens
21 BAP1 8314
Negative Genetic Homo sapiens
22 ADPRHL2 54936
Co-fractionation Homo sapiens
23 C21orf33  
Proximity Label-MS Homo sapiens
24 SSBP1 6742
Proximity Label-MS Homo sapiens
25 GRHPR 9380
Co-fractionation Homo sapiens
26 NUDT9 53343
Co-fractionation Homo sapiens
27 IDH2 3418
Co-fractionation Homo sapiens
28 AARS2  
Proximity Label-MS Homo sapiens
29 CYP11A1  
Reconstituted Complex Homo sapiens
30 PRDX6 9588
Co-fractionation Homo sapiens
31 TPI1 7167
Co-fractionation Homo sapiens
32 CMPK1 51727
Co-fractionation Homo sapiens
33 ACO2 50
Co-fractionation Homo sapiens
34 GPATCH8  
Affinity Capture-MS Homo sapiens
35 COA7  
Co-fractionation Homo sapiens
36 PGM1 5236
Co-fractionation Homo sapiens
37 PRKAB2 5565
Two-hybrid Homo sapiens
38 FDX1L  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
39 ATP5B 506
Co-fractionation Homo sapiens
40 Cdc26  
Affinity Capture-MS Mus musculus
41 HIF1A 3091
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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