Gene description for FDX1
Gene name ferredoxin 1
Gene symbol FDX1
Other names/aliases ADX
FDX
LOH11CR1D
Species Homo sapiens
 Database cross references - FDX1
ExoCarta ExoCarta_2230
Entrez Gene 2230
HGNC 3638
MIM 103260
UniProt P10109  
 FDX1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for FDX1
Molecular Function
    electron carrier activity GO:0009055 IDA
    iron ion binding GO:0005506 TAS
    2 iron, 2 sulfur cluster binding GO:0051537 IDA
Biological Process
    sterol metabolic process GO:0016125 TAS
    cholesterol metabolic process GO:0008203 IDA
    xenobiotic metabolic process GO:0006805 TAS
    C21-steroid hormone biosynthetic process GO:0006700 TAS
    oxidation-reduction process GO:0055114 IEA
    small molecule metabolic process GO:0044281 TAS
    hormone biosynthetic process GO:0042446 IDA
    steroid metabolic process GO:0008202 TAS
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified FDX1 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for FDX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FDXR  
Invitro Homo sapiens
2 CYP11A1  
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
3 CYP11B2  
Invitro Homo sapiens
View the network image/svg+xml



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