Gene description for ADPRHL2
Gene name ADP-ribosylhydrolase like 2
Gene symbol ADPRHL2
Other names/aliases ARH3
Species Homo sapiens
 Database cross references - ADPRHL2
ExoCarta ExoCarta_54936
Entrez Gene 54936
HGNC 21304
MIM 610624
UniProt Q9NX46  
 ADPRHL2 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ADPRHL2
Molecular Function
    poly(ADP-ribose) glycohydrolase activity GO:0004649 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    metabolic process GO:0008152 IEA
    cellular response to superoxide GO:0071451 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrial matrix GO:0005759 IEA
 Experiment description of studies that identified ADPRHL2 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ADPRHL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C10orf4  
Two-hybrid Homo sapiens
2 FLJ23825  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ADPRHL2 is involved
No pathways found





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