Gene description for NUDT9
Gene name nudix (nucleoside diphosphate linked moiety X)-type motif 9
Gene symbol NUDT9
Other names/aliases NUDT10
Species Homo sapiens
 Database cross references - NUDT9
ExoCarta ExoCarta_53343
Vesiclepedia VP_53343
Entrez Gene 53343
HGNC 8056
MIM 606022
UniProt Q9BW91  
 NUDT9 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Saliva 19199708    
 Gene ontology annotations for NUDT9
Molecular Function
    protein binding GO:0005515 IPI
    ADP-sugar diphosphatase activity GO:0019144 NAS
    ADP-ribose diphosphatase activity GO:0047631 EXP
    ADP-ribose diphosphatase activity GO:0047631 IDA
Biological Process
    ADP catabolic process GO:0046032 IEA
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    cytosol GO:0005829 IDA
    nuclear body GO:0016604 IDA
    cell junction GO:0030054 IDA
    nuclear membrane GO:0031965 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified NUDT9 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for NUDT9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAGEB10  
Affinity Capture-MS Homo sapiens
2 DPP6  
Affinity Capture-MS Homo sapiens
3 IMPA2 3613
Co-fractionation Homo sapiens
4 GSTO1 9446
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
5 TRUB1 142940
Affinity Capture-MS Homo sapiens
6 FDX1 2230
Co-fractionation Homo sapiens
7 CPOX 1371
Co-fractionation Homo sapiens
8 HARS2 23438
Affinity Capture-MS Homo sapiens
9 MAN2A1 4124
Co-fractionation Homo sapiens
10 GCSH 2653
Co-fractionation Homo sapiens
11 APRT 353
Co-fractionation Homo sapiens
12 PHPT1 29085
Co-fractionation Homo sapiens
13 FAHD1 81889
Affinity Capture-MS Homo sapiens
14 CALM1 801
Affinity Capture-MS Homo sapiens
15 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 DDX58 23586
Affinity Capture-RNA Homo sapiens
17 PBX3  
Two-hybrid Homo sapiens
18 APP 351
Reconstituted Complex Homo sapiens
19 ASNA1 439
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 UGDH 7358
Co-fractionation Homo sapiens
21 DUT 1854
Co-fractionation Homo sapiens
22 SLC2A2  
Affinity Capture-MS Homo sapiens
23 LCN9  
Affinity Capture-MS Homo sapiens
24 TRIM11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 NIT1 4817
Co-fractionation Homo sapiens
26 EPHA2 1969
Two-hybrid Homo sapiens
27 PGM3 5238
Co-fractionation Homo sapiens
28 WDR5B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 KRAS 3845
Synthetic Lethality Homo sapiens
30 APBA1  
Affinity Capture-MS Homo sapiens
31 SLC39A7 7922
Affinity Capture-MS Homo sapiens
32 LMF1 64788
Affinity Capture-MS Homo sapiens
33 HSPD1 3329
Cross-Linking-MS (XL-MS) Homo sapiens
34 C15orf57  
Affinity Capture-MS Homo sapiens
35 IMPA1 3612
Co-fractionation Homo sapiens
36 PHGDH 26227
Co-fractionation Homo sapiens
View the network image/svg+xml



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