Gene description for TRUB1
Gene name TruB pseudouridine (psi) synthase family member 1
Gene symbol TRUB1
Other names/aliases PUS4
Species Homo sapiens
 Database cross references - TRUB1
ExoCarta ExoCarta_142940
Vesiclepedia VP_142940
Entrez Gene 142940
HGNC 16060
MIM 610726
UniProt Q8WWH5  
 TRUB1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for TRUB1
Molecular Function
    protein binding GO:0005515 IPI
    pseudouridine synthase activity GO:0009982 IBA
    pseudouridine synthase activity GO:0009982 IDA
    pre-miRNA binding GO:0070883 IDA
    tRNA pseudouridine(55) synthase activity GO:0160148 IEA
Biological Process
    mRNA processing GO:0006397 IEA
    tRNA modification GO:0006400 IBA
    tRNA modification GO:0006400 IDA
    mRNA pseudouridine synthesis GO:1990481 IBA
    mRNA pseudouridine synthesis GO:1990481 IDA
    positive regulation of pre-miRNA processing GO:2000633 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 HTP
    cytosol GO:0005829 IDA
 Experiment description of studies that identified TRUB1 in exosomes
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRUB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLPP 8192
Proximity Label-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 TRAF2 7186
Affinity Capture-MS Homo sapiens
4 NUDT9 53343
Affinity Capture-MS Homo sapiens
5 XPO1 7514
Affinity Capture-MS Homo sapiens
6 PKM 5315
Affinity Capture-MS Homo sapiens
7 CD72  
Affinity Capture-MS Homo sapiens
8 FBXO25  
Biochemical Activity Homo sapiens
9 SSB 6741
Affinity Capture-MS Homo sapiens
10 SETMAR  
Affinity Capture-MS Homo sapiens
11 CAND1 55832
Affinity Capture-MS Homo sapiens
12 TCEAL1  
Affinity Capture-MS Homo sapiens
13 APP 351
Reconstituted Complex Homo sapiens
14 PRPS2 5634
Affinity Capture-MS Homo sapiens
15 USP11 8237
Affinity Capture-MS Homo sapiens
16 CAPG 822
Affinity Capture-MS Homo sapiens
17 SLC2A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CASP3 836
Co-fractionation Homo sapiens
19 SERBP1 26135
Affinity Capture-MS Homo sapiens
20 FLYWCH2  
Co-fractionation Homo sapiens
21 SNW1 22938
Affinity Capture-MS Homo sapiens
22 MTFMT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TRUB1 is involved
No pathways found





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