Gene description for PHPT1
Gene name phosphohistidine phosphatase 1
Gene symbol PHPT1
Other names/aliases CGI-202
HEL-S-132P
HSPC141
PHP14
Species Homo sapiens
 Database cross references - PHPT1
ExoCarta ExoCarta_29085
Entrez Gene 29085
HGNC 30033
MIM 610167
UniProt Q9NRX4  
 PHPT1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PHPT1
Molecular Function
    calcium channel inhibitor activity GO:0019855 IDA
    phosphohistidine phosphatase activity GO:0008969 IMP
    phosphoprotein phosphatase activity GO:0004721 IEA
    ion channel binding GO:0044325 IPI
Biological Process
    negative regulation of T cell receptor signaling pathway GO:0050860 IMP
    peptidyl-histidine dephosphorylation GO:0035971 IDA
    protein dephosphorylation GO:0006470 IDA
    regulation of actin cytoskeleton reorganization GO:2000249 IMP
    negative regulation of ATP citrate synthase activity GO:2000984 IDA
    positive regulation of cell motility GO:2000147 IMP
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IEA
    negative regulation of lyase activity GO:0051350 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified PHPT1 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PHPT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP1R16A  
Two-hybrid Homo sapiens
2 DNMT3L  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PHPT1 is involved
No pathways found





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