Gene description for PPP2R4
Gene name protein phosphatase 2A activator, regulatory subunit 4
Gene symbol PPP2R4
Other names/aliases PP2A
Species Homo sapiens
 Database cross references - PPP2R4
ExoCarta ExoCarta_5524
Entrez Gene 5524
HGNC 9308
MIM 600756
UniProt Q15257  
 PPP2R4 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for PPP2R4
Molecular Function
    receptor binding GO:0005102 IPI
    protein heterodimerization activity GO:0046982 TAS
    ATPase activity GO:0016887 IDA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    protein phosphatase 2A binding GO:0051721 IDA
    protein homodimerization activity GO:0042803 IDA
    ATP binding GO:0005524 IDA
    protein phosphatase type 2A regulator activity GO:0008601 TAS
    protein tyrosine phosphatase activator activity GO:0008160 IDA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of phosphoprotein phosphatase activity GO:0032516 IDA
    protein peptidyl-prolyl isomerization GO:0000413 IEA
    metabolic process GO:0008152 IDA
    negative regulation of phosphoprotein phosphatase activity GO:0032515 IDA
    regulation of phosphoprotein phosphatase activity GO:0043666 IDA
    positive regulation of apoptotic process GO:0043065 IDA
    mitotic spindle organization in nucleus GO:0030472 IBA
    negative regulation of protein dephosphorylation GO:0035308 IDA
    regulation of protein phosphatase type 2A activity GO:0034047 TAS
    positive regulation of protein dephosphorylation GO:0035307 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    protein phosphatase type 2A complex GO:0000159 IDA
    nucleoplasm GO:0005654 IDA
    calcium channel complex GO:0034704 IDA
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified PPP2R4 in exosomes
Experiment ID 191
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2R4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RRD2  
Affinity Capture-Western 4932
2 CCNG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
3 STRN3 29966
Affinity Capture-Western Homo sapiens
4 BCL2  
Biochemical Activity Homo sapiens
5 JAK2 3717
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 CCNG2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PPP2R4 is involved
No pathways found

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