Gene description for PPP2R4
Gene name protein phosphatase 2A activator, regulatory subunit 4
Gene symbol PPP2R4
Other names/aliases PP2A
PR53
PTPA
Species Homo sapiens
 Database cross references - PPP2R4
ExoCarta ExoCarta_5524
Vesiclepedia VP_5524
Entrez Gene 5524
HGNC 9308
MIM 600756
UniProt Q15257  
 PPP2R4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for PPP2R4
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    phosphoprotein phosphatase activity GO:0004721 IDA
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    protein tyrosine phosphatase activator activity GO:0008160 IBA
    protein tyrosine phosphatase activator activity GO:0008160 IDA
    protein phosphatase regulator activity GO:0019888 IDA
    protein phosphatase regulator activity GO:0019888 TAS
    phosphatase binding GO:0019902 IDA
    protein homodimerization activity GO:0042803 IDA
    metal ion binding GO:0046872 IEA
    protein phosphatase 2A binding GO:0051721 IDA
    RNA polymerase II CTD heptapeptide repeat P3 isomerase activity GO:0140839 IEA
    RNA polymerase II CTD heptapeptide repeat P6 isomerase activity GO:0140840 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    mitotic spindle organization GO:0007052 IBA
    positive regulation of apoptotic process GO:0043065 IDA
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 IBA
    protein phosphatase type 2A complex GO:0000159 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    calcium channel complex GO:0034704 IDA
    extracellular exosome GO:0070062 HDA
    ATPase complex GO:1904949 IDA
 Experiment description of studies that identified PPP2R4 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 363
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 364
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 365
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2R4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 NIF3L1 60491
Two-hybrid Homo sapiens
3 SLC25A3 5250
Affinity Capture-MS Homo sapiens
4 PPP2R3A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 ARRB2 409
Affinity Capture-Western Homo sapiens
6 MYLPF 29895
Affinity Capture-MS Homo sapiens
7 PPP4C 5531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 FOXO3  
Affinity Capture-MS Homo sapiens
9 CCT8 10694
Affinity Capture-MS Homo sapiens
10 MYOCD  
Affinity Capture-MS Homo sapiens
11 CCT3 7203
Affinity Capture-MS Homo sapiens
12 AMOT  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 CCT5 22948
Affinity Capture-MS Homo sapiens
14 PPP4R2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 GFI1B  
Affinity Capture-MS Homo sapiens
16 BHLHB9 80823
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
17 CCT2 10576
Affinity Capture-MS Homo sapiens
18 RACGAP1 29127
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
19 CCNE1  
Biochemical Activity Homo sapiens
20 CCT6A 908
Affinity Capture-MS Homo sapiens
21 SP1  
Affinity Capture-Western Homo sapiens
22 LAP3 51056
Co-fractionation Homo sapiens
23 PPP1CA 5499
Affinity Capture-Western Homo sapiens
24 FAM110C  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
25 TCP1 6950
Affinity Capture-MS Homo sapiens
26 UBE4B 10277
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 PTEN 5728
Affinity Capture-Western Homo sapiens
28 4932438A13Rik  
Affinity Capture-MS Mus musculus
29 CCT4 10575
Affinity Capture-MS Homo sapiens
30 ATM 472
Affinity Capture-Western Homo sapiens
31 F3 2152
Biochemical Activity Homo sapiens
32 ANXA3 306
Co-fractionation Homo sapiens
33 MID1 4281
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
34 IER3  
Affinity Capture-Western Homo sapiens
35 CCDC125 202243
Two-hybrid Homo sapiens
36 DDX58 23586
Affinity Capture-RNA Homo sapiens
37 SMEK1 55671
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 APP 351
Reconstituted Complex Homo sapiens
39 CCT7 10574
Affinity Capture-MS Homo sapiens
40 NXF1 10482
Affinity Capture-RNA Homo sapiens
41 ESR1  
Affinity Capture-MS Homo sapiens
42 SULT4A1  
Biochemical Activity Homo sapiens
43 AURKB 9212
Biochemical Activity Homo sapiens
44 ACOT13  
Co-fractionation Homo sapiens
45 TUBA1A 7846
Affinity Capture-Western Homo sapiens
46 USP8 9101
Affinity Capture-Western Homo sapiens
47 DDAH2 23564
Co-fractionation Homo sapiens
48 MARK2 2011
Affinity Capture-Western Homo sapiens
49 PHPT1 29085
Co-fractionation Homo sapiens
50 MOV10 4343
Affinity Capture-RNA Homo sapiens
51 MDM2  
Affinity Capture-Western Homo sapiens
52 PPP2R1A 5518
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
53 MYH9 4627
Affinity Capture-MS Homo sapiens
54 SP3  
Affinity Capture-Western Homo sapiens
55 SET 6418
Affinity Capture-Western Homo sapiens
56 EGFR 1956
Affinity Capture-Western Homo sapiens
57 MAPT  
Biochemical Activity Homo sapiens
58 CYP17A1 1586
Affinity Capture-Western Homo sapiens
59 BRINP1  
Affinity Capture-MS Homo sapiens
60 PPP2CA 5515
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
61 SERBP1 26135
Affinity Capture-MS Homo sapiens
62 GRIN3A  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
63 EZH2  
Affinity Capture-Western Homo sapiens
64 CCNG1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
65 MAP2K3 5606
Affinity Capture-Western Homo sapiens
66 NPM1 4869
Affinity Capture-Western Homo sapiens
67 MAPK14 1432
Affinity Capture-Western Homo sapiens
68 PRKCB 5579
Biochemical Activity Homo sapiens
69 AKT1 207
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
70 EIF4EBP1  
Biochemical Activity Homo sapiens
71 HDAC4  
Reconstituted Complex Homo sapiens
72 STK26 51765
Affinity Capture-Western Homo sapiens
73 CAV1 857
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
74 KISS1R  
Reconstituted Complex Homo sapiens
75 PPP2CB 5516
Affinity Capture-MS Homo sapiens
76 CYLD  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
77 CT45A5  
Affinity Capture-MS Homo sapiens
78 H2AFX 3014
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which PPP2R4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here