Gene description for ANKRD17
Gene name ankyrin repeat domain 17
Gene symbol ANKRD17
Other names/aliases GTAR
MASK2
NY-BR-16
Species Homo sapiens
 Database cross references - ANKRD17
ExoCarta ExoCarta_26057
Entrez Gene 26057
HGNC 23575
MIM 615929
UniProt O75179  
 ANKRD17 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ANKRD17
Molecular Function
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    chromatin binding GO:0003682 IDA
Biological Process
    positive regulation of MDA-5 signaling pathway GO:1900245 IDA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IMP
    negative regulation of smooth muscle cell differentiation GO:0051151 IEA
    positive regulation of RIG-I signaling pathway GO:1900246 IDA
    viral process GO:0016032 IEA
    innate immune response GO:0045087 IDA
    defense response to bacterium GO:0042742 IDA
    positive regulation of cell cycle GO:0045787 IMP
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IDA
    blood vessel maturation GO:0001955 IEA
    regulation of DNA replication GO:0006275 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    chromatin GO:0000785 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified ANKRD17 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ANKRD17
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ANKRD17 is involved
No pathways found





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