Gene description for HOXB7
Gene name homeobox B7
Gene symbol HOXB7
Other names/aliases HHO.C1
HOX2
HOX2C
Hox-2.3
Species Homo sapiens
 Database cross references - HOXB7
ExoCarta ExoCarta_3217
Entrez Gene 3217
HGNC 5118
MIM 142962
UniProt P09629  
 HOXB7 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for HOXB7
Molecular Function
    protein binding GO:0005515 IPI
    sequence-specific DNA binding transcription factor activity GO:0003700 NAS
    sequence-specific DNA binding GO:0043565 IEA
Biological Process
    anterior/posterior pattern specification GO:0009952 IEA
    myeloid cell differentiation GO:0030099 IEA
    transcription, DNA-templated GO:0006351 IEA
    multicellular organismal development GO:0007275 NAS
    embryonic skeletal system morphogenesis GO:0048704 IEA
    regulation of transcription, DNA-templated GO:0006355 NAS
    positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 NAS
 Experiment description of studies that identified HOXB7 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for HOXB7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PBX1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 NFKBIA  
Invivo Homo sapiens
3 CREBBP  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HOXB7 is involved
No pathways found





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