Gene description for HOXB6
Gene name homeobox B6
Gene symbol HOXB6
Other names/aliases HOX2
Species Homo sapiens
 Database cross references - HOXB6
ExoCarta ExoCarta_3216
Entrez Gene 3216
HGNC 5117
MIM 142961
UniProt P17509  
 HOXB6 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for HOXB6
Molecular Function
    sequence-specific DNA binding GO:0043565 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    transcription, DNA-templated GO:0006351 IEA
    embryonic skeletal system morphogenesis GO:0048704 IEA
    erythrocyte homeostasis GO:0034101 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified HOXB6 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for HOXB6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SAT  
Two-hybrid Homo sapiens
2 PLSCR1 5359
Two-hybrid Homo sapiens
3 PKNOX1  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
4 KRT15 3866
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HOXB6 is involved
No pathways found

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