Gene description for LONP1
Gene name lon peptidase 1, mitochondrial
Gene symbol LONP1
Other names/aliases CODASS
LON
LONP
LonHS
PIM1
PRSS15
hLON
Species Homo sapiens
 Database cross references - LONP1
ExoCarta ExoCarta_9361
Entrez Gene 9361
HGNC 9479
MIM 605490
UniProt P36776  
 LONP1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for LONP1
Molecular Function
    ADP binding GO:0043531 IDA
    G-quadruplex DNA binding GO:0051880 IDA
    mitochondrial heavy strand promoter sense binding GO:0070364 IDA
    protein binding GO:0005515 IPI
    serine-type endopeptidase activity GO:0004252 IEA
    ATP binding GO:0005524 IDA
    mitochondrial light strand promoter anti-sense binding GO:0070361 IDA
    single-stranded RNA binding GO:0003727 IDA
    ATP-dependent peptidase activity GO:0004176 IDA
    mitochondrial heavy strand promoter anti-sense binding GO:0070362 IDA
    mitochondrial light strand promoter sense binding GO:0070363 IDA
    DNA polymerase binding GO:0070182 IPI
    single-stranded DNA binding GO:0003697 IBA
    sequence-specific DNA binding GO:0043565 IDA
Biological Process
    oxidation-dependent protein catabolic process GO:0070407 IMP
    regulation of mitochondrial DNA replication GO:0090296 IEA
    mitochondrial DNA metabolic process GO:0032042 NAS
    cellular response to oxidative stress GO:0034599 IDA
    proteolysis involved in cellular protein catabolic process GO:0051603 IDA
    response to hormone GO:0009725 IEA
    misfolded or incompletely synthesized protein catabolic process GO:0006515 IBA
    chaperone-mediated protein complex assembly GO:0051131 IBA
    response to aluminum ion GO:0010044 IEA
    aging GO:0007568 IEA
    response to hypoxia GO:0001666 IEP
    mitochondrion organization GO:0007005 IMP
    mitochondrial genome maintenance GO:0000002 NAS
    protein homooligomerization GO:0051260 IDA
Subcellular Localization
    mitochondrial nucleoid GO:0042645 IDA
    cytoplasm GO:0005737 IDA
    mitochondrial matrix GO:0005759 IMP
    mitochondrion GO:0005739 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified LONP1 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LONP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LONP1 is involved
No pathways found





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