Gene description for FTSJ2
Gene name FtsJ RNA methyltransferase homolog 2 (E. coli)
Gene symbol FTSJ2
Other names/aliases FJH1
HEL97
MRM2
RRMJ2
Species Homo sapiens
 Database cross references - FTSJ2
ExoCarta ExoCarta_29960
Vesiclepedia VP_29960
Entrez Gene 29960
HGNC 16352
MIM 606906
UniProt Q9UI43  
 FTSJ2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for FTSJ2
Molecular Function
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 EXP
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 IBA
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 IMP
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 NAS
Biological Process
    rRNA 2'-O-methylation GO:0000451 TAS
    RNA methylation GO:0001510 IBA
    rRNA processing GO:0006364 IMP
    rRNA processing GO:0006364 NAS
    rRNA methylation GO:0031167 NAS
    mitochondrial large ribosomal subunit assembly GO:1902775 IMP
Subcellular Localization
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISS
    mitochondrial matrix GO:0005759 IMP
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified FTSJ2 in exosomes
1
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for FTSJ2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDUFAF1  
Affinity Capture-MS Homo sapiens
2 FTL 2512
Affinity Capture-MS Homo sapiens
3 KBTBD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ZMYND19  
Affinity Capture-MS Homo sapiens
5 GLS 2744
Affinity Capture-MS Homo sapiens
6 METTL17  
Affinity Capture-MS Homo sapiens
7 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 TSPAN5 10098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MRPL16  
Affinity Capture-MS Homo sapiens
11 ACSF2 80221
Affinity Capture-MS Homo sapiens
12 PREPL 9581
Affinity Capture-MS Homo sapiens
13 RNF123 63891
Affinity Capture-MS Homo sapiens
14 VWA8 23078
Affinity Capture-MS Homo sapiens
15 BCKDK 10295
Affinity Capture-MS Homo sapiens
16 UBAC1 10422
Affinity Capture-MS Homo sapiens
17 ALDH4A1 8659
Affinity Capture-MS Homo sapiens
18 MTERF3  
Affinity Capture-MS Homo sapiens
19 MTIF2 4528
Affinity Capture-MS Homo sapiens
20 PNPT1 87178
Affinity Capture-MS Homo sapiens
21 UQCC1 55245
Affinity Capture-MS Homo sapiens
22 IMPDH1 3614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 HECTD3 79654
Affinity Capture-MS Homo sapiens
24 LONP1 9361
Affinity Capture-MS Homo sapiens
25 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 BRCA1 672
Affinity Capture-MS Homo sapiens
27 MTG2  
Proximity Label-MS Homo sapiens
28 PI15  
Affinity Capture-MS Homo sapiens
29 GID4  
Affinity Capture-MS Homo sapiens
30 CDK5RAP1  
Affinity Capture-MS Homo sapiens
31 CRAT 1384
Affinity Capture-MS Homo sapiens
32 CNP 1267
Affinity Capture-MS Homo sapiens
33 MCCC1 56922
Affinity Capture-MS Homo sapiens
34 FAHD1 81889
Affinity Capture-MS Homo sapiens
35 ZNF131  
Affinity Capture-MS Homo sapiens
36 GATB  
Affinity Capture-MS Homo sapiens
37 MRRF  
Affinity Capture-MS Homo sapiens
38 NDUFAF7  
Affinity Capture-MS Homo sapiens
39 WDR26 80232
Affinity Capture-MS Homo sapiens
40 TMEM74  
Affinity Capture-MS Homo sapiens
41 NDUFA10 4705
Affinity Capture-MS Homo sapiens
42 POLDIP2 26073
Affinity Capture-MS Homo sapiens
43 CPS1 1373
Affinity Capture-MS Homo sapiens
44 ATPAF1  
Affinity Capture-MS Homo sapiens
45 ARMC8 25852
Affinity Capture-MS Homo sapiens
46 IDE 3416
Affinity Capture-MS Homo sapiens
47 RNH1 6050
Affinity Capture-MS Homo sapiens
48 DARS2 55157
Affinity Capture-MS Homo sapiens
49 LARS2 23395
Affinity Capture-MS Homo sapiens
50 UBR1 197131
Affinity Capture-MS Homo sapiens
51 NDUFA2 4695
Affinity Capture-MS Homo sapiens
52 SREBF2 6721
Negative Genetic Homo sapiens
53 YARS2  
Affinity Capture-MS Homo sapiens
54 GID8 54994
Affinity Capture-MS Homo sapiens
55 AARS2  
Affinity Capture-MS Homo sapiens
56 RANBP10 57610
Affinity Capture-MS Homo sapiens
57 MGME1  
Affinity Capture-MS Homo sapiens
58 TSFM 10102
Affinity Capture-MS Homo sapiens
59 MIPEP  
Affinity Capture-MS Homo sapiens
60 NIT1 4817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 FECH 2235
Affinity Capture-MS Homo sapiens
62 ACSF3 197322
Affinity Capture-MS Homo sapiens
63 RMND5A 64795
Affinity Capture-MS Homo sapiens
64 CLPX 10845
Affinity Capture-MS Homo sapiens
65 CELA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 CAMK2D 817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 TMLHE 55217
Affinity Capture-MS Homo sapiens
68 PCCA 5095
Affinity Capture-MS Homo sapiens
69 MRPL12 6182
Affinity Capture-MS Homo sapiens
70 SLC31A1 1317
Affinity Capture-MS Homo sapiens
71 HSPD1 3329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 DDX58 23586
Affinity Capture-RNA Homo sapiens
73 PUS1 80324
Affinity Capture-MS Homo sapiens
74 MKLN1  
Affinity Capture-MS Homo sapiens
75 PCCB 5096
Affinity Capture-MS Homo sapiens
76 MALSU1  
Affinity Capture-MS Homo sapiens
77 PTCD1 26024
Affinity Capture-MS Homo sapiens
78 MAEA 10296
Affinity Capture-MS Homo sapiens
79 PIPSL 266971
Affinity Capture-MS Homo sapiens
80 ZZEF1 23140
Affinity Capture-MS Homo sapiens
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