Gene description for PUS1
Gene name pseudouridylate synthase 1
Gene symbol PUS1
Other names/aliases MLASA1
Species Homo sapiens
 Database cross references - PUS1
ExoCarta ExoCarta_80324
Entrez Gene 80324
HGNC 15508
MIM 608109
UniProt Q9Y606  
 PUS1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for PUS1
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    pseudouridylate synthase activity GO:0004730 NAS
    ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 IEA
    pseudouridine synthase activity GO:0009982 IEA
Biological Process
    tRNA pseudouridine synthesis GO:0031119 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
Subcellular Localization
    nucleolus GO:0005730 IEA
    mitochondrion GO:0005739 IDA
    nuclear chromatin GO:0000790 IEA
    nucleus GO:0005634 IDA
    transcription factor complex GO:0005667 IEA
 Experiment description of studies that identified PUS1 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PUS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PUS1 is involved
No pathways found





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