Gene description for WDR12
Gene name WD repeat domain 12
Gene symbol WDR12
Other names/aliases YTM1
Species Homo sapiens
 Database cross references - WDR12
ExoCarta ExoCarta_55759
Entrez Gene 55759
HGNC 14098
UniProt Q9GZL7  
 WDR12 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for WDR12
Molecular Function
    protein binding GO:0005515 IPI
    ribonucleoprotein complex binding GO:0043021 IEA
Biological Process
    ribosomal large subunit biogenesis GO:0042273 IC
    Notch signaling pathway GO:0007219 IEA
    maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000463 IMP
    maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000466 IMP
    cell proliferation GO:0008283 IMP
Subcellular Localization
    nucleolus GO:0005730 IDA
    PeBoW complex GO:0070545 IDA
    preribosome, large subunit precursor GO:0030687 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified WDR12 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for WDR12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which WDR12 is involved
No pathways found





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