Gene description for IGHMBP2
Gene name immunoglobulin mu binding protein 2
Gene symbol IGHMBP2
Other names/aliases CATF1
CMT2S
HCSA
HMN6
SMARD1
SMUBP2
ZFAND7
Species Homo sapiens
 Database cross references - IGHMBP2
ExoCarta ExoCarta_3508
Vesiclepedia VP_3508
Entrez Gene 3508
HGNC 5542
MIM 600502
UniProt P38935  
 IGHMBP2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for IGHMBP2
Molecular Function
    ATP binding GO:0005524 IDA
    tRNA binding GO:0000049 IDA
    transcription factor binding GO:0008134 IPI
    protein binding GO:0005515 IPI
    DNA helicase activity GO:0003678 TAS
    ribosome binding GO:0043022 IDA
    DNA binding GO:0003677 IDA
    single-stranded DNA binding GO:0003697 TAS
    DNA-dependent ATPase activity GO:0008094 IDA
    RNA binding GO:0003723 IDA
    ATP-dependent 5'-3' DNA helicase activity GO:0043141 IDA
    ATP-dependent 5'-3' RNA helicase activity GO:0032575 IDA
    zinc ion binding GO:0008270 IEA
    RNA-dependent ATPase activity GO:0008186 IDA
Biological Process
    DNA replication GO:0006260 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
    translation GO:0006412 NAS
    DNA duplex unwinding GO:0032508 TAS
    transcription, DNA-templated GO:0006351 IEA
    DNA recombination GO:0006310 TAS
    protein homooligomerization GO:0051260 IDA
    DNA repair GO:0006281 TAS
Subcellular Localization
    growth cone GO:0030426 ISS
    cytoplasm GO:0005737 IDA
    axon GO:0030424 ISS
    nucleus GO:0005634 IDA
    ribonucleoprotein complex GO:0030529 ISS
    membrane GO:0016020 IDA
    SMN complex GO:0032797 IDA
 Experiment description of studies that identified IGHMBP2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IGHMBP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LSM8 51691
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which IGHMBP2 is involved
No pathways found





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