Gene description for NELFCD
Gene name negative elongation factor complex member C/D
Gene symbol NELFCD
Other names/aliases HSPC130
NELF-C
NELF-D
TH1
TH1L
Species Homo sapiens
 Database cross references - NELFCD
ExoCarta ExoCarta_51497
Entrez Gene 51497
HGNC 15934
MIM 605297
UniProt Q8IXH7  
 NELFCD identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for NELFCD
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    viral process GO:0016032 TAS
    positive regulation of viral transcription GO:0050434 TAS
    gene expression GO:0010467 TAS
    transcription from RNA polymerase II promoter GO:0006366 TAS
    transcription elongation from RNA polymerase II promoter GO:0006368 TAS
    negative regulation of transcription, DNA-templated GO:0045892 IEA
Subcellular Localization
    NELF complex GO:0032021 IDA
    nucleoplasm GO:0005654 TAS
    membrane GO:0016020 IDA
 Experiment description of studies that identified NELFCD in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NELFCD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MTA1  
Two-hybrid Homo sapiens
2 COX6C  
Affinity Capture-MS Homo sapiens
3 SERF2 10169
Two-hybrid Homo sapiens
4 MCM7 4176
Affinity Capture-MS Homo sapiens
5 PHB2 11331
Affinity Capture-MS Homo sapiens
6 COX6B1  
Affinity Capture-MS Homo sapiens
7 COX5B 1329
Affinity Capture-MS Homo sapiens
8 RPS11 6205
Affinity Capture-MS Homo sapiens
9 COX5A  
Affinity Capture-MS Homo sapiens
10 RDBP  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
11 COX2  
Affinity Capture-MS Homo sapiens
12 EIF4G1 1981
Affinity Capture-MS Homo sapiens
13 ARPC4 10093
Two-hybrid Homo sapiens
14 WHSC2  
Reconstituted Complex Homo sapiens
15 SMAD4  
Affinity Capture-MS Homo sapiens
16 HDAC11  
Two-hybrid Homo sapiens
17 CCAR2 57805
Affinity Capture-MS Homo sapiens
18 EPRS 2058
Two-hybrid Homo sapiens
19 GSTM4  
Two-hybrid Homo sapiens
20 RPS26 6231
Affinity Capture-MS Homo sapiens
21 RPS14 6208
Affinity Capture-MS Homo sapiens
22 COPB2 9276
Affinity Capture-MS Homo sapiens
23 DNPEP 23549
Affinity Capture-MS Homo sapiens
24 DNAJA1 3301
Two-hybrid Homo sapiens
25 NELFB 25920
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
26 ARAF 369
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 COX4I1 1327
Affinity Capture-MS Homo sapiens
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