Gene description for PRSS3
Gene name protease, serine, 3
Gene symbol PRSS3
Other names/aliases MTG
PRSS4
T9
TRY3
TRY4
Species Homo sapiens
 Database cross references - PRSS3
ExoCarta ExoCarta_5646
Entrez Gene 5646
HGNC 9486
MIM 613578
UniProt P35030  
 PRSS3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PRSS3
Molecular Function
    serine-type endopeptidase activity GO:0004252 IDA
    serine-type peptidase activity GO:0008236 IDA
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 IDA
Biological Process
    cobalamin metabolic process GO:0009235 TAS
    zymogen activation GO:0031638 IDA
    small molecule metabolic process GO:0044281 TAS
    vitamin metabolic process GO:0006766 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
    digestion GO:0007586 TAS
    innate immune response GO:0045087 TAS
    endothelial cell migration GO:0043542 IMP
    proteolysis GO:0006508 NAS
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified PRSS3 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRSS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Invitro Homo sapiens
2 TFPI 7035
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which PRSS3 is involved
PathwayEvidenceSource
Alpha-defensins TAS Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism TAS Reactome





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