Gene description for FOLR1
Gene name folate receptor 1 (adult)
Gene symbol FOLR1
Other names/aliases FBP
FOLR
Species Homo sapiens
 Database cross references - FOLR1
ExoCarta ExoCarta_2348
Entrez Gene 2348
HGNC 3791
MIM 136430
UniProt P15328  
 FOLR1 identified in exosomes derived from the following tissue/cell type
Breast milk 17641064    
Saliva 19199708    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for FOLR1
Molecular Function
    receptor activity GO:0004872 TAS
    folic acid transporter activity GO:0008517 IMP
    folic acid binding GO:0005542 NAS
Biological Process
    folic acid metabolic process GO:0046655 IEA
    receptor-mediated endocytosis GO:0006898 TAS
    folic acid transport GO:0015884 IMP
Subcellular Localization
    membrane GO:0016020 TAS
    plasma membrane GO:0005886 NAS
    clathrin-coated vesicle GO:0030136 IEA
    nucleus GO:0005634 IDA
    anchored component of external side of plasma membrane GO:0031362 IDA
    brush border membrane GO:0031526 IEA
    endosome GO:0005768 IEA
    cell surface GO:0009986 IDA
    extracellular exosome GO:0070062 IDA
    integral component of plasma membrane GO:0005887 TAS
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified FOLR1 in exosomes
1
Experiment ID 48
ISEV standards
EM|IEM
EV Biophysical techniques
HSC70
EV Cytosolic markers
CD63|CD86|MHCII
EV Membrane markers
CANX
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Mature milk
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
2
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
3
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FOLR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FOLR1 is involved
No pathways found





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