Gene description for XPNPEP3
Gene name X-prolyl aminopeptidase 3, mitochondrial
Gene symbol XPNPEP3
Other names/aliases APP3
ICP55
NPHPL1
Species Homo sapiens
 Database cross references - XPNPEP3
ExoCarta ExoCarta_63929
Entrez Gene 63929
HGNC 28052
MIM 613553
UniProt Q9NQH7  
 XPNPEP3 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for XPNPEP3
Molecular Function
    metallopeptidase activity GO:0008237 IEA
    aminopeptidase activity GO:0004177 IMP
    manganese ion binding GO:0030145 IEA
Biological Process
    protein processing GO:0016485 IMP
    glomerular filtration GO:0003094 IMP
Subcellular Localization
    mitochondrion GO:0005739 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified XPNPEP3 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for XPNPEP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which XPNPEP3 is involved
No pathways found





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