Gene description for XPNPEP3
Gene name X-prolyl aminopeptidase 3, mitochondrial
Gene symbol XPNPEP3
Other names/aliases APP3
ICP55
NPHPL1
Species Homo sapiens
 Database cross references - XPNPEP3
ExoCarta ExoCarta_63929
Vesiclepedia VP_63929
Entrez Gene 63929
HGNC 28052
MIM 613553
UniProt Q9NQH7  
 XPNPEP3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for XPNPEP3
Molecular Function
    aminopeptidase activity GO:0004177 IBA
    aminopeptidase activity GO:0004177 IMP
    protein binding GO:0005515 IPI
    manganese ion binding GO:0030145 IDA
    protein homodimerization activity GO:0042803 IPI
    metalloaminopeptidase activity GO:0070006 IDA
Biological Process
    glomerular filtration GO:0003094 IMP
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IDA
    protein processing GO:0016485 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified XPNPEP3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for XPNPEP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
2 ANLN 54443
Affinity Capture-MS Homo sapiens
3 CLPP 8192
Proximity Label-MS Homo sapiens
4 MRPL57  
Affinity Capture-MS Homo sapiens
5 MECP2 4204
Affinity Capture-MS Homo sapiens
6 TNFRSF1B  
Affinity Capture-MS Homo sapiens
7 NES 10763
Affinity Capture-MS Homo sapiens
8 OBSL1 23363
Affinity Capture-MS Homo sapiens
9 DFNB31  
Affinity Capture-MS Homo sapiens
10 DNAAF1  
Affinity Capture-MS Homo sapiens
11 TP53 7157
Affinity Capture-MS Homo sapiens
12 FOLR1 2348
Affinity Capture-MS Homo sapiens
13 PYY  
Affinity Capture-MS Homo sapiens
14 CHGA  
Affinity Capture-MS Homo sapiens
15 RIN3  
Affinity Capture-MS Homo sapiens
16 PRMT1 3276
Affinity Capture-MS Homo sapiens
17 CHMP4C 92421
Affinity Capture-MS Homo sapiens
18 GLB1 2720
Affinity Capture-MS Homo sapiens
19 GCDH 2639
Affinity Capture-MS Homo sapiens
20 C2orf47  
Affinity Capture-MS Homo sapiens
21 GFAP 2670
Affinity Capture-MS Homo sapiens
22 CUL3 8452
Affinity Capture-MS Homo sapiens
23 KIF20A 10112
Affinity Capture-MS Homo sapiens
24 ECH1 1891
Affinity Capture-MS Homo sapiens
25 XPNPEP3 63929
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 C8orf37  
Affinity Capture-MS Homo sapiens
27 CST6  
Affinity Capture-MS Homo sapiens
28 SOX2  
Affinity Capture-MS Homo sapiens
29 HNRNPK 3190
Affinity Capture-MS Homo sapiens
30 NT5DC2 64943
Affinity Capture-MS Homo sapiens
31 AURKB 9212
Affinity Capture-MS Homo sapiens
32 IDE 3416
Affinity Capture-MS Homo sapiens
33 CLN5  
Affinity Capture-MS Homo sapiens
34 C12orf49  
Negative Genetic Homo sapiens
35 UBR5 51366
Affinity Capture-MS Homo sapiens
36 LSMEM2  
Affinity Capture-MS Homo sapiens
37 PRC1 9055
Affinity Capture-MS Homo sapiens
38 RELL1 768211
Affinity Capture-MS Homo sapiens
39 KIF23 9493
Affinity Capture-MS Homo sapiens
40 SEC16A 9919
Affinity Capture-MS Homo sapiens
41 CHCHD2  
Affinity Capture-MS Homo sapiens
42 POLDIP2 26073
Affinity Capture-MS Homo sapiens
43 C1QBP 708
Affinity Capture-MS Homo sapiens
44 LDLR 3949
Negative Genetic Homo sapiens
45 DYRK2 8445
Affinity Capture-MS Homo sapiens
46 ALYREF 10189
Affinity Capture-MS Homo sapiens
47 KAZALD1  
Affinity Capture-MS Homo sapiens
48 MRPL53  
Affinity Capture-MS Homo sapiens
49 BIRC7  
Affinity Capture-MS Homo sapiens
50 PAK7  
Affinity Capture-MS Homo sapiens
51 GAS2L1 10634
Affinity Capture-MS Homo sapiens
52 VIM 7431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 NR3C1 2908
Affinity Capture-MS Homo sapiens
54 LACE1  
Affinity Capture-MS Homo sapiens
55 ZYG11B  
Affinity Capture-MS Homo sapiens
56 IL31  
Affinity Capture-MS Homo sapiens
57 TCF25 22980
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which XPNPEP3 is involved
No pathways found





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