Gene description for GAS2L1
Gene name growth arrest-specific 2 like 1
Gene symbol GAS2L1
Other names/aliases GAR22
Species Homo sapiens
 Database cross references - GAS2L1
ExoCarta ExoCarta_10634
Vesiclepedia VP_10634
Entrez Gene 10634
HGNC 16955
MIM 602128
UniProt Q99501  
 GAS2L1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GAS2L1
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IDA
    microtubule binding GO:0008017 IEA
    cytoskeletal anchor activity GO:0008093 IDA
    actin filament binding GO:0051015 IBA
Biological Process
    microtubule bundle formation GO:0001578 IBA
    microtubule bundle formation GO:0001578 IMP
    negative regulation of microtubule depolymerization GO:0007026 IMP
    cellular response to starvation GO:0009267 ISS
    regulation of microtubule polymerization or depolymerization GO:0031110 IBA
    regulation of microtubule polymerization or depolymerization GO:0031110 IMP
    actin crosslink formation GO:0051764 IBA
    protein localization to microtubule plus-end GO:1904825 IBA
    protein localization to microtubule plus-end GO:1904825 IDA
Subcellular Localization
    stress fiber GO:0001725 IBA
    stress fiber GO:0001725 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    microtubule GO:0005874 IDA
    actin filament GO:0005884 IMP
    microtubule plus-end GO:0035371 IBA
    microtubule plus-end GO:0035371 IMP
 Experiment description of studies that identified GAS2L1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GAS2L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 P3H1 64175
Affinity Capture-MS Homo sapiens
2 GPSM2  
Two-hybrid Homo sapiens
3 NAGK 55577
Affinity Capture-MS Homo sapiens
4 GSN 2934
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PPP1CB 5500
Affinity Capture-MS Homo sapiens
6 USP7 7874
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SPRR3 6707
Affinity Capture-MS Homo sapiens
8 Myh9 17886
Affinity Capture-MS Mus musculus
9 POT1  
Two-hybrid Homo sapiens
10 Racgap1 26934
Affinity Capture-MS Mus musculus
11 KLHL8  
Affinity Capture-MS Homo sapiens
12 HECTD3 79654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 Smad3  
Affinity Capture-MS Mus musculus
14 Myo1c 17913
Affinity Capture-MS Mus musculus
15 ZZEF1 23140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 WDR45B 56270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CAPZA2 830
Affinity Capture-MS Homo sapiens
18 MAPRE2 10982
Affinity Capture-MS Homo sapiens
19 XPNPEP3 63929
Affinity Capture-MS Homo sapiens
20 MYO19  
Affinity Capture-MS Homo sapiens
21 RBM12 10137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 Actb 11461
Affinity Capture-MS Mus musculus
23 DDX58 23586
Affinity Capture-RNA Homo sapiens
24 TMOD1  
Affinity Capture-MS Homo sapiens
25 MAPRE1 22919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 KLHL42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MAPRE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CCNB1 891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 GNB1L 54584
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 BTBD1  
Affinity Capture-MS Homo sapiens
31 Mapre1 13589
Affinity Capture-MS Mus musculus
32 LRRFIP1 9208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SNX5 27131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 DIS3 22894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 EPN1 29924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 IQGAP1 8826
Affinity Capture-MS Homo sapiens
37 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CKS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CDKN2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 PLCG1 5335
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CRTAP 10491
Affinity Capture-MS Homo sapiens
42 NXN 64359
Affinity Capture-MS Homo sapiens
43 CD2AP 23607
Affinity Capture-MS Homo sapiens
44 RTEL1 51750
Affinity Capture-MS Homo sapiens
45 CRNN 49860
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GAS2L1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here