Gene description for SRSF8
Gene name serine/arginine-rich splicing factor 8
Gene symbol SRSF8
Other names/aliases DSM-1
SFRS2B
SRP46
Species Homo sapiens
 Database cross references - SRSF8
ExoCarta ExoCarta_10929
Entrez Gene 10929
HGNC 16988
MIM 603269
UniProt Q9BRL6  
 SRSF8 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SRSF8
Molecular Function
    nucleotide binding GO:0000166 IEA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    RNA splicing GO:0008380 IEA
    mRNA processing GO:0006397 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified SRSF8 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SRSF8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SRSF8 is involved
No pathways found





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