Gene description for NOLC1
Gene name nucleolar and coiled-body phosphoprotein 1
Gene symbol NOLC1
Other names/aliases NOPP130
Species Homo sapiens
 Database cross references - NOLC1
ExoCarta ExoCarta_9221
Entrez Gene 9221
HGNC 15608
MIM 602394
UniProt Q14978  
 NOLC1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for NOLC1
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
    ATP binding GO:0005524 IEA
Biological Process
    cell cycle GO:0007049 TAS
    rRNA processing GO:0006364 TAS
    nucleolus organization GO:0007000 IEA
    mitotic nuclear division GO:0007067 TAS
Subcellular Localization
    nucleoplasm GO:0005654 IBA
    cytoplasm GO:0005737 IEA
    Cajal body GO:0015030 IEA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified NOLC1 in exosomes
Experiment ID 191
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NOLC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR1A  
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Phenotypic Enhancement Homo sapiens
Reconstituted Complex Homo sapiens
3 YWHAZ 7534
Affinity Capture-MS Homo sapiens
4 CSNK2B 1460
Invivo Homo sapiens
Invitro Homo sapiens
5 USP4 7375
Invivo Homo sapiens
6 COIL  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
7 ARRB1 408
Affinity Capture-MS Homo sapiens
8 ARRB2  
Affinity Capture-MS Homo sapiens
9 GTF2B 2959
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which NOLC1 is involved
No pathways found

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